Central dogma is the most fundamental hypothesis in field of molecular biology and explains genetic information flow from DNA to protein. Beyond residue-by-residue transmission sequential information, chemical modifications DNA, RNA, protein are also relayed course gene expression. Here, this work presents recent evidence supporting bidirectional interplay between chromatin RNA modifications. F...

Earlier we introduced (M.I.Trofimov, E.A.Smolenskii, Application of the Electronegativity Indices of Organic Molecules to Tasks of Chemical Informatics, Russian Chemical Bulletin 54(2005), 2235-2246. http://dx.doi.org/10.1007/s11172-006-0105-6) effective recursive algorithm for graph isomorphism testing. In this paper we describe used approach and iterative modification of this algorithm, which...

The exquisite selectivity of chemical reactions enables the study of rare DNA bases. However, chemical modification of the genome can affect downstream analysis. We report a PCR bias caused by such modification, and exemplify a solution with the synthesis and characterization of a cleavable aldehyde-reactive biotinylation probe.

Chemical modification is an important approach to the study of enzyme active sites. This article presents an overview of the methods used. The basic concepts, applications and limitations of chemical modification are outlined. The use of reagents specific for different amino acid side chains is also discussed.

The objective of this paper was to examine the effect that chemical modification of raw material had on fire resistance of two panel products, namely Oriented Strand Board (OSB) and particleboard and to investigate the influence of the anhydride type. The results have shown that chemical modification affected the ignition and glowing time of two wood panel products.

Recent successes in clinical trials have provided important proof of concept that small interfering RNAs (siRNAs) indeed constitute a new promising class of therapeutics. Although great efforts are still needed to ensure efficient means of delivery in vivo, the siRNA molecule itself has been successfully engineered by chemical modification to meet initial challenges regarding specificity, stabi...

Nucleic acids are attractive materials for creating functional molecules that have applications as catalysts, specific binders, and molecular switches. Nucleic acids having such functions can be obtained by random screening, typically using in vitro selection methods. These methods have helped explore the potential abilities of nucleic acids and steadily contributed to their evolution, i.e., cr...