Purpose Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly accumulated in tumors with little drug exposure to normal tissues. However, many PTX-loaded micelle formulations suffer from low stability, fast drug release, and lack of tumor-targeting capability in the circulation. To overcom...

BACKGROUND Life at altitude depends on adaptation to ambient hypoxia. In the Andes, susceptibility to chronic mountain sickness (CMS), a clinical condition that occurs to native highlanders or to sea level natives with prolonged residence at high altitude, remains poorly understood. We hypothesized that hypoxia-associated gene expression in children of men with CMS might identify markers that p...

like myasthenia gravis, congenital myasthenic syndrome (cms) produces weakness and fatigue caused by problems at the neuromuscular junction but while mg is autoimmune, cms is an inherited disease caused by defective genes. genes defective in cms are required for making the ach receptor or other components of the neuromuscular junction. cmss are inherited in an ar, or, less frequently, ad manner...

BACKGROUND Establishment of a biological pacemaker is expected to solve the persisting problems of a mechanical pacemaker including the problems of battery life and electromagnetic interference. Enhancement of the funny current (If) flowing through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and attenuation of the inward rectifier K+ current (IK1) flowing through inward r...

We present the methods for off-line -jet identification developed for the study of decay modes of the neutral SUSY Higgses of mass 140 300 GeV in CMS. Detector response is simulated with a GEANT-based package CMSIM. Involving calorimetry and tracker information, -jet selection criteria allow to reduce the backgrounds to an acceptable level while keeping the selection efficiency at the level of ...

Around 15 years ago, I started to collaborate with Sony (Sony Ericsson at the time) on designing compact multiantennas for multiple-input, multiple-output (MIMO) terminals. It wasn’t long before realized that mutual coupling between two antenna elements was extreme low cellular band (below 1 GHz), even though they were placed as far away from each other possible terminal chassis. This higher th...

BACKGROUND Chronic mountain sickness (CMS) has a higher incidence in the plateau region. The one of its principal characters is excessive erythrocytosis. The PI3K-Akt pathway plays an important role in the process of erythropoiesis, and could downregulate apoptosis by regulating apoptosis-related molecules. In this paper, we explored the change in apoptosis of erythroblasts and the effect of th...

BACKGROUND Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can recapitulate features of ion channel mutations causing inherited rhythm disease. However, the lack of maturity of these cells is considered a significant limitation of the model. Prolonged culture of hiPSC-CMs promotes maturation of these cells. We studied the electrophysiological effects of the I230T mutation...

We scan the parameter space of the NMSSM for the observability of at least one Higgs boson at the LHC with 300 fb integrated luminosity, taking the present LEP2 constraints into account. We restrict the scan to those regions of parameter space for which Higgs boson decays to other Higgs bosons and/or supersymmetric particles are kinematically forbidden. We find that if WW -fusion detection mode...