Bid, a proapoptotic member of Bcl-2 family, is involved in Fas receptor signaling. Fas activation promotes human eosinophil cell death and is believed to accelerate the resolution of pulmonary Th2-driven allergic reaction in mice. We hypothesized that Bid would regulate eosinophil apoptosis and Ag-induced airway inflammation, particularly eosinophilia. C57BL/6 Bid(-/-) and wild-type mice were i...

In this work we introduce the class of graphs with bounded induced distance of order k, (BID(k) for short). A graph G belongs to BID(k) if the distance between any two nodes in every connected induced subgraph of G is at most k times their distance in G. These graphs can model communication networks in which node failures may occur: at a given time, if sender and receiver are still connected, a...

We consider the problem faced by a seller in determining an optimal price to quote in response to a Request for Quote (RFQ) from a prospective buyer. The optimal price is determined by maximizing expected profit, given the underlying seller costs of the bid items and a computed probability of winning the bid as a function of price and other bid features such as buyer characteristics and the deg...

The pathophysiology of atherosclerosis involves a diseased endothelium, lipid accumulation and low-grade inflammation. In later stages of coronary artery disease (CAD) and peripheral arterial disease (PAD), plaque rupture may induce atherothrombosis caused by fibrin formation and platelet activation, leading to vessel occlusion with subsequent organ damage such as myocardial infarction, stroke ...

EC.1. Proof of Theorem 1 Consider a bidder A with type v t in an auction where every other bidder uses strategy , where is an arbitrary threshold function. If A is not the first bidder, the first bidder has either placed a bid or exercised the option immediately (following strategy ), so that the buyout option is no longer available to bidder A. In that case bidder A’s weakly dominant strategy ...

Auctions on the Internet provide a new source of data on how bidding is in uenced by the detailed rules of the auction. Here we study the second-price auctions run by eBay and Amazon, in which a bidder submits a reservation price and has this (maximum) price used to bid for him by proxy. That is, a bidder can submit his reservation price (called a proxy bid) early in the auction and have the r...

We present results from a series of experiments with human subjects at the University of Maryland Subjects participated as suppliers in an auction, each with the capacity to supply up to two units of a good, and bid to supply a portion of the buyer's fixed demand of 3 units. We study the performance of 3 different auction formats: (1) uniform-price one-part bid, (2) uniform-price two-part bid, ...

AIM A network meta-analysis of the three new oral anticoagulants was performed from the three trials comparing dabigatran, rivaroxaban and apixaban with warfarin in patients with atrial fibrillation. METHODS Data were extracted of the RE-LY study of dabigatran 110 mg bid and dabigatran 150 mg bid, the ROCKET AF trial of rivaroxaban and the ARISTOTLE trial of apixaban for the composite outcome...

Bid is an abundant proapoptotic protein of the Bcl-2 family that is crucial for the induction of death receptor-mediated apoptosis in primary tissues such as liver. Bid action has been proposed to involve the relocation of its truncated form, tBid, to mitochondria to facilitate the release of apoptogenic cytochrome c. The mechanism of Bid relocation to mitochondria was unclear. We report here n...