The faithful duplication and preservation of our genetic material is essential for cell survival; however, DNA is susceptible to damage by extracellular and intracellular agents (e.g. ultraviolet radiation, reactive oxygen species). DNA double-strand breaks (DSBs) are thought to represent the most dangerous type of lesion, as the failure to repair a DSB can lead to loss of genetic information, ...

PARK2 (Parkin) is an extremely large gene that spans greater than 1.3 megabases of genomic sequence within chromosomal band 6q26. This gene is derived from within the distal end of the highly unstable FRA6E (6q26) common fragile site (CFS). CFSs are large chromosomal regions that are highly unstable, found in all individuals, and prone to deletions and other alterations, especially in developin...

Shutdown of cell cycle progression by checkpoint activation is the exception rather than norm when cells face physiological levels replication stress.In response to endogenous stress, use tunable deceleration and brake release mechanisms under control ATR CHK1 kinases for timely completion DNA duplication.Intrinsic activation, maintenance, recovery represent a continuum, which modulated phospho...

In this paper we present the results of an international comparative research conducted through a special web survey, i.e. an online ‘game’ to rate and classify Critical Success Factors (CFSs) for BPMS implementations. The survey was completed by 39 respondents from 11 different countries. Central to the research was the question how BPM-systems success factors are perceived by professionals fr...