BACKGROUND Previously we showed that the release properties of a liposomal ciprofloxacin (CFI) formulation could be attenuated by incorporation of drug nanocrystals within the vesicles. Rather than forming these drug nanocrystals during drug loading, they were created post manufacture simply by freezing and thawing the formulation. The addition of surfactant to CFI, either polysorbate 20 or Bri...

BACKGROUND The efficacy of granulocyte colony-stimulating factor (G-CSF) for coronary collateral growth promotion and thus impending myocardial salvage has not been studied so far, to our best knowledge. METHODS AND RESULTS In 52 patients with chronic stable coronary artery disease, age 62+/-11 years, the effect on a marker of myocardial infarct size (ECG ST segment elevation) and on quantita...

In this paper, we propose a new feature selection method for hyperspectral images. Firstly, the bands are selected by combining the information entropy, classification separability and correlation coefficients with the Choquet fuzzy integral. After that, maximum likelihood classification method is used for the classification. Experiments on the AVIRIS dataset show that the proposed method remov...

Ultrasound Color Flow Imaging (CFI) has become a valuable tool in a wide rangeof medical applications where information about blood flow can be related to thediagnosis of disease, as for instance in the cardiovascular system. The modalityprovides a map of blood velocity and direction in a twoor three-dimensional regionof interest, where abnormal blood flow patterns can be detect...

Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Coronary Artery Disease To the Editor: The study by Seiler et al1 on collateral growth stimulation in humans by granulocyte-macrophage colony-stimulating factor (GM-CSF) received a very optimistic editorial by Schaper.2 The authors should be congratulated on the study concept and the conduct of this first-time approach to assess ...

Alternative polyadenylation (APA) is a widespread gene regulatory mechanism that generates mRNAs with different 3'-ends, allowing them to interact with different sets of RNA regulators such as microRNAs and RNA-binding proteins. Recent studies have shown that during development, neural tissues produce mRNAs with particularly long 3'UTRs, suggesting that such extensions might be important for ne...

The coupled cluster method ~CCM! is applied to a spin-half model at zero temperature which interpolates between a triangular lattice antiferromagnet ~TAF! and a kagomé lattice antiferromagnet ~KAF!. The strength of the bonds which connect kagomé lattice sites is J, and the strength of the bonds which link the non-kagomé lattice sites to the kagomé lattice sites on an underlying triangular latti...