Rosai-Dorfman disease (RDD) is a type of sinus histiocytosis. It rare (1:200000), particularly in children and commonly presents with massive, painless usually bilateral cervical lymphadenopathy along fever weight loss. Leukocytosis, elevated erythrocyte sedimentation rate hypergammaglobulinemia are common. A definitive diagnosis can only be made by histological analysis affected lymph nodes. E...

R osai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare idiopathic disorder of histiocytic proliferation. According to a review of the entity by Foucar et al (1), the typical patient profile is a 20year-old white or black male who presents with painless bilateral cervical lymphadenopathy. The clinical course is variable ranging from self-limited ...

Immune-mediated drug reactions are a potentially life-threatening complication of antiseizure medications. Drug hypersensitivity syndrome (DHS) is the best recognised of these, presenting with fever, eosinophilia, rash and internal organ involvement. Isolated lymphadenopathy is a less recognized immune-mediated reaction to antiseizure drugs such as lamotrigine. We describe the case of a 24-year...

We describe a rare case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) associated with a six-year history of autoimmune pancreatitis, which was controlled by steroid treatment. The patient presented with multiple, cervical and thoracic lymphadenopathy and abnormal, nodular opacities in the lung. Histologically, Rosai-Dorfman disease with numerous IgG4-positive cells...