We conducted a structural genomics analysis of the folds and structural superfamilies in the first 20 completely sequenced genomes by focusing on the patterns of fold usage and trying to identify structural characteristics of typical and atypical folds. We assigned folds to sequences using PSI-blast, run with a systematic protocol to reduce the amount of computational overhead. On average, fold...

We conducted a structural genomics analysis of the folds and structural superfamilies in the first 20 completely sequenced genomes by focusing on the patterns of fold usage and trying to identify structural characteristics of typical and atypical folds. We assigned folds to sequences using PSI-blast, run with a systematic protocol to reduce the amount of computational overhead. On average, fold...

PURPOSE To determine the frequency, patterns, associations, and biomechanical implications of retinal and choroidal folds in papilledema due to idiopathic intracranial hypertension (IIH). METHODS Retinal and choroidal folds were studied in patients enrolled in the IIH Treatment Trial using fundus photography (n = 165 study eyes) and spectral-domain optical coherence tomography (SD-OCT; n = 12...

Eight microbial genomes are compared in terms of protein structure. Specifically, yeast, H. influenzae, M. genitalium, M. jannaschii, Synechocystis, M. pneumoniae, H. pylori, and E. coli are compared in terms of patterns of fold usage-whether a given fold occurs in a particular organism. Of the approximately 340 soluble protein folds currently in the structure databank (PDB), 240 occur in at le...

Microscopic billow-like wavy folds have been observed along slip planes of the Nojima active fault, southwest Japan. The folds are similar in form to Kelvin–Helmholtz (KH) instabilities occurring in fluids, which implies that the slip zone underwent “lubrication” such as frictional melting or fluidization of fault gouge materials. If the temperature range for generation of the billow-like wavy ...

EmrAB operon is known for multidrug resistance in bacteria and yet has not been reported related to heavy metal resistance or antibiotics/heavy metal co-resistance. Strain Staphylococcus aureus LZ-01 which was isolated from industrial wastewater discharging site can co-resist to 6 mM Cr(VI) and 0.75 mg/ml ampicillin. Transcriptome data showed that an emrAB operon was upregulated (1.29-folds for...

Ventricular dysphonia, also known as dysphonia plicae ventricularis, is a disorder of speech in which the ventricular folds (false vocal folds, FVFs) participate pathologically in phonation. 1,2 Although the first anatomic illustrations of the false folds were done in 1775 by Santorini ,3 their role in phonation was not completely understood. In 1860, 6 years after the introduction of the laryn...

It has been known that topologically different proteins of the same class sometimes share the same spatial arrangement of secondary structure elements (SSEs). However, the frequency by which topologically different structures share the same spatial arrangement of SSEs is unclear. It is important to estimate this frequency because it provides both a deeper understanding of the geometry of protei...

In this study, four-dimensional $N=1$ F-theory models with multiple U(1) gauge group factors are constructed. A class of rational elliptic 4-folds, which we call as "$\frac{1}{2}$Calabi-Yau 4-folds," is introduced, and construct the elliptically fibered 4-folds by utilizing them. This yields a novel approach for building families Calabi-Yau positive Mordell-Weil ranks. The introduced $\frac{1}{...