OBJECTIVE After brain injury intracranial hypertension is the major cause of mortality, in addition to the possibility of functional, behavioral and cognitive sequels. Scarcity of studies on the effects of respiratory physiotherapy on these patients may lead to contradictory performances. This study aimed to assess the effects of customary respiratory physiotherapy maneuvers on intracranial and...

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...

Brain Injury Mechanisms of Brain Injury Hypoxia and Ischemia Excitatory Amino Acid Injury Cerebral Edema Increased Intracranial Volume and Pressure Brain Herniation Hydrocephalus Traumatic Head and Brain Injury Skull Fractures Traumatic Brain Injury Manifestations of Global Brain Injury Anatomic and Physiologic Basis of Consciousness Reticular Activating System Levels of Consciousness Other Man...

BACKGROUND The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged contralateral ovarian tissue were investigated in rats, biochemically and histologically. MATERIALS AND METHODS In this experimental study, 40 rats were equally divided into four groups: 10 mg/kg moclobemide, 20 mg/kg moclobemide, ischemia/reperfusion control, and intact control groups...

Xin-Shao formula is a folk remedy widely used in China to prevent and cure stroke. Cerebral ischemic reperfusion (I/R) injury often takes place during the treatment of stroke. Information about the pharmacokinetic behavior of the remedy under cerebral I/R injury conditions is lacking. The present study aimed to compare the pharmacokinetic properties of scutellarin and paeoniflorin, two major bi...

Surgical repair of the ascending aorta and aortic arch that employs cardiopulmonary bypass (CPB), often with the use of deep hypothermic circulatory arrest (DHCA), allows for lifesaving therapy. In doing so, however, it also represents a unique injury paradigm leading to derangements in numerous homeostatic pathways. Organ injury, most notably cerebral injury, may result as a consequence of the...

This study was conducted to determine the incidence of cerebral injury as detected by postnatal brain scan in monochorionic twins with selective intrauterine growth restriction. Having excluded cases complicated with twin-to-twin transfusion syndrome and one co-twin suffering intrauterine fetal death, a total of 73 monochorionic twin pregnancies divided into absence (group I, n = 46) or presenc...

Traumatic cerebral vascular injury (TCVI) is a frequent, perhaps universal, feature after traumatic brain injury (TBI) and may be responsible for for some TBI-related chronic disabilities. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature (CMV) ...

introduction: development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. blood brain barrier (bbb) opening is an important part of edema named as vasogenic brain edema. in this study, quantitative alterations of bbb permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. methods: two groups of male rats (ischemic and sh...

Current recommendations regarding the management of patients after traumatic brain injury include reduction in brain tissue pressure (i.e. intracranial pressure) and maintenance of an adequate arterial pressure; these measures combined should result in cerebral perfusion pressure sufficient to achieve adequate oxygen delivery. After almost 20 years of observational studies comparing cerebral pe...