Due to their short-range (2–500 nm), Auger electrons (Auger e−) have the potential induce nano-scale physiochemical damage biomolecules. Although DNA is primary target of e−, it remains challenging maximize interaction between e− and DNA. To assess DNA-damaging effect released as close possible without chemical damage, we radio-synthesized no-carrier-added (n.c.a.) [189, 191Pt]cisplatin evaluat...

Introduction: Glass ionomer cement (GIC) is a restorative material used in pediatric dentistry, which attaches to dental hard tissues and has cariostatic properties due to the ability for fluoride release. The present study aimed to assess the fluoride release and uptake capacity of two GICs in the presence of various fluoride sources. Methods: This in-vitro study was conducted on 120 disks com...

Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...

Ehrlich ascites-tumour cells accumulate Ca2+ when incubated aerobically with succinate, phosphate and rotenone, as revealed by isotopic and atomic-absorption measurements. Ca2+ does not stimulate oxygen consumption by carefully prepared Ehrlich cells, but des so when the cells are placed in a hypo-osmotic medium. Neither glutamate nor malate support Ca2+ uptake in 'intact' Ehrlich cells, nor do...

c-myb antisense oligonucleotides (AS ODNs) were reversibly immobilized to a novel polymeric core shell nanosphere and their cellular uptake and inhibitory effect on HL60 leukemia cell proliferation studied. The nanosphere surface was so designed as to directly bind ODNs via ionic interactions and reversibly release them inside the cells. Compared with the cellular uptake of free oligonucleotide...

Exosomes are nano-vesicles secreted by a wide range of mammalian cell types. These vesicles are abundant in serum and other extracellular fluids and contain a large repertoire of proteins, mRNA and microRNA. Exosomes have been implicated in cell to cell communication, the transfer of infectious agents, and neurodegenerative diseases as well as tumor progression. However, the precise mechanisms ...

Glial cells play an important role in sequestering neuronally released glutamate via Na+-dependent transporters. Surprisingly, these transporters are not operational in glial-derived tumors (gliomas). Instead, gliomas release glutamate, causing excitotoxic death of neurons in the vicinity of the tumor. We now show that glutamate release from glioma cells is an obligatory by-product of cellular ...

Background—Several studies have suggested that epinephrine augments the release of norepinephrine from sympathetic nerve terminals through stimulation of presynaptic receptors, but evidence pertaining to this mechanism in the heart is scarce and conflicting. Using the microdialysis technique in the porcine heart, we investigated whether epinephrine, taken up by and released from cardiac sympath...

Nanoparticles are currently becoming one of the important parts for various segments. Much more process/application becomes effective or economical and time-saving because nanoparticles. Polymers with distinct characteristics widely used but nature-origin polymer has properties that make a polymeric material Many methods were successfully evaluated to prepare chitosan nanoparticles loading comp...