Abstract Background and Aims: The number of new cancer cases with considerable mortality is increasing worldwide. Since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. Gene therapy has widespread systemic cytotoxic effects against tumor cells. Rotavirus NSP4 has been shown to...

The p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. Pancreatic tumor cells show a very high frequency of p53 mutation. To determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, PANC-1 and HTB80, differing in p53 status were stably transfected with exogenous wil...

case presentation in november 2015, a 31-year-old pregnant woman at gestational week 12 of her second pregnancy was referred to our private clinic in rasht, iran. she had microscopic hematuria; a mass measuring 39 × 33 mm in the upper portion of her right kidney was was detected by ultrasonography. conclusions a percutaneous renal mass biopsy was used, instead of nephrectomy, to diagnose the ma...

the cytotoxicity activity of the essential oils from the leaves of achillea wilhelmsii c. koch were studied on six tumor cell lines and a normal cell line w

Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological pathological conditions. They contain signature tumor-derived molecules that reflect intracellular status their cell origin. Recent studies have shown tumor cell-derived EVs can aid cancer metastasis through modula...

We aimed to develop a cost-effective and robust method to predict drug resistance in individualpatients. Representative tissue fragments were obtained from tumors removed from femalepatients, aged 24-74 years old. The tumor tissue was taken by a histopathology’s or a surgeonunder sterile conditions. Cells obtained by enzymatic dissociation from tumor after surgery, werecultured as a monolayer f...

We aimed to develop a cost-effective and robust method to predict drug resistance in individualpatients. Representative tissue fragments were obtained from tumors removed from femalepatients, aged 24-74 years old. The tumor tissue was taken by a histopathology’s or a surgeonunder sterile conditions. Cells obtained by enzymatic dissociation from tumor after surgery, werecultured as a monolayer f...

background: in this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. previous research showed a cytotoxic effect of adenosine via a3 receptor and a1 receptor and sometimes this effect was receptor independent. the researches showed a differential cytotoxic effect of adenosine and its a3 agonists on cancerous cells, while ot...