Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with relapsing-remitting (RR) course, manifesting as sporadic attacks neurological symptoms including ataxia, fatigue, sensory impairment. While there are several effective disease-modifying therapies able to address relaps...

Multiple sclerosis (MS) has long been considered a T-cell-mediated autoimmune disease of the central nervous system. However, newer evidence shows that B cells play crucial role in pathogenesis MS via antibody production, antigen presentation, T cell stimulation and activation, production pro-inflammatory cytokines. Developing express CD20 molecule from pre-B to plasmablast stage, anti-CD20 mon...