Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...

Cell-selective regulation of protein translocation is achieved through the rational design an endogenous enzyme-operated spherical nucleic acids platform. The system enables enzyme-activated capture proteins interest and thus their cytoplasmic-nuclear shuttling with tumor-cell specificity, as reported by Mengyuan Li co-workers in Research Article (e202214958).

background: micropatterning is becoming a powerful tool for studying cells in vitro. this method not only uses very small amount of material but also mimic the microenvironment structure present in living tissues better than flask culturing techniques. in previous studies using micropatterning of extracellular matrix proteins on glass surfaces, the rate of protein detachment from the surface wa...

Multiple experimental investigations have been successful in suggesting the role of heat shock protein as a clinical biomarker and therapeutic target several diseases. All living cells, from simplest prokaryote to most complex multicellular organism, contain proteins-molecular chaperones that are responsible for management unfolded polypeptides within cell. In view fundamental proteins maintena...

A versatile non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins, permitted the sell functionalization.

background: the development and progression of human tumors is accompanied by various cellular biochemical and genetic alterations. these events include tumor cells interaction with extracellular matrix molecules including hyaluronan and hyaluronan binding protein (ha-habp). hyaluronan is a large polysaccharide associated with pericellular matrix of proliferating, migrating cells, regulation of...