Epithelial to mesenchymal transition (EMT) is a biological process that plays a crucial role in cancer metastasis. Although studies regarding the EMT mechanisms are usual in terms of gene expression and protein functions, little is known about the involvement of lipids in EMT. In this work, an untargeted lipidomic analysis was performed to reveal which lipids are involved in the EMT process. DU...

One of the fundamental problems in membrane biology is that of lipid diversity. The number of chemically different membrane lipids is much larger than other key biological building blocks such as nucleotides, amino acids, and carbohydrates. For instance, a relatively simple biomembrane such as that of the red blood cell contains well over a hundred different lipid species. Except for some metab...

background and objective: basal cell carcinoma (bcc) and squamous cell carcinoma (scc) are two common tumors of the skin. in some cases, distinction between bcc and scc can be difficult. this study aimed to clarify this uncertainty through immunohistochemical analysis. in this respect, epithelial membrane antigen (ema) and ber-ep4 are the two immunohistochemical markers on which we focus in dif...

You wouldn't call it a long-term relationship, but the interaction between proteins and certain membrane lipids is not just a one-millisecond stand. As Hammond et al. discovered, the proteins remain attached to the lipids longer than researchers expected. The fi ndings explain how these lipids localize their effects. By temporarily hooking up with various proteins, inositol lipids in the plasma...

Pulsed field ablation (PFA) is a nonthermal ablative energy modality that increases membrane permeability by creating pores and causing chemical changes to the lipids proteins on cell membrane. However, little known about its effect membrane, organelle structure time course of lesion formation. To evaluate after PFA assess differences between 1- 4-hour PFA. Healthy swine underwent endocardial u...

While it is known that lipids play an essential role in regulating membrane protein structure and function, remains challenging to identify specific protein–lipid interactions.

You wouldn't call it a long-term relationship, but the interaction between proteins and certain membrane lipids is not just a one-millisecond stand. As Hammond et al. discovered, the proteins remain attached to the lipids longer than researchers expected. The fi ndings explain how these lipids localize their effects. By temporarily hooking up with various proteins, inositol lipids in the plasma...

Cell membranes are dynamic assemblies of a variety of lipids and proteins. They form a protective layer around the cell, but also mediate the communication with the outside world – that is, neighboring cells in a tissue, hormones and growth factors arriving with the blood supply, or pathogens trying to enter the system. The unique feature of cell membranes is that their lipid and protein consti...

Cholesterol is an important component of cell plasma membrane. Due to its chemical composition (long rigid hydrophobic chain and a small polar hydroxyl group), it fits most of its structure into the lipid bilayer, where its steroid rings are in close proximity and attracted to the hydrocarbon chains of neighboring lipids. This gives a condensing effect on the packing of lipids in cell membranes...