Background: Neurofollicular hamartoma (NFH) is characterized histopathologically by fascicles of spindle cells that laterally delimited by hyperplastic folliculosebaceous units. It usually appears on face, near the nose or nasolabial fold. It does not manifest true neural differentiation and recently the term spindle cell predominant trichodiscoma (SCPT) has been used instead. Case Presentatio...

Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...

Mantle cell lymphoma is an aggressive B-cell malignancy. Current frontline chemoimmunotherapies produce high response rates but relapse inevitable. Furthermore, the elderly and those with comorbidities are precluded from standard regimens stem transplant, leaving them limited options. Targeted therapies, including Bruton tyrosine kinase inhibitors, effective treatment strategy in mantle lymphom...

Intravascular large B-cell Lymphoma (IVLBCL) is a rare subtype of extranodal non-Hodgkin’s lymphoma that challenging to diagnose and has poor prognosis. Here, we describe two patients newly diagnosed with IVLBCL at our institution: an African man hemophagocytic-syndrome-associated Italian woman cutaneous variant IVLBCL. They presented very different clinical manifestations. Both cases were in t...

We herein report a patient who presented with follicular lymphoma. Although the stomach was initially intact, mucosal redness and multiple erosions appeared in gastric body owing to infiltration of lymphoma cells. Subsequently, slightly depressed, white area lacking structure detected lesser curvature cardia body, where cell also pathologically observed beneath stratified squamous epithelium. T...

Background: Immunophenotyping and improvement in classification system of lymphoma gains better epidemiological comparison incidence pattern. We aimed to study the spectrum clinic-epidemiological profile categorize type subtype according 2008 WHO system. Methods: This hospital-based retrospective, cross-sectional included all cases diagnosed a 5-year period from January 2012 December 2016. Demo...

Introduction: Previous reviews of phase 1 trials in oncology have reported a treatment response rate 4%–6% and toxicity-related mortality 0.5%. These results may not reflect current Phase trial rates for patients with lymphoma. Methods: All non-pediatric relapsed or refractory (R/R) lymphoma approved by the Cancer Therapy Evaluation Program Institut Gustave Roussy between 2008 2023 (cut-off dat...

BACKGROUND There is increasing evidence that stromal cell interactions are required for the survival and drug resistance of several types of B-cell malignancies. There is relatively little information regarding the role of the bone marrow/lymphoid microenvironment in the pathogenesis of mantle cell lymphoma. In this study we investigated the interaction of primary mantle cell lymphoma cells wit...