BACKGROUND Chronic inflammatory diseases are common in cats and mesenchymal stem cells (MSC) are a promising therapeutic approach for management of these disorders. The purpose of this study was to evaluate the safety of intraperitoneal injection of MSC in cats. HYPOTHESIS Intrapertioneal injection of autologous MSC in cats is safe. ANIMALS Ten healthy adult purpose-bred cats. METHODS Mes...

BACKGROUND When this trial was initiated, the combined measles, mumps and rubella (MMR) vaccine was licensed for subcutaneous administration in all European countries and for intramuscular administration in some countries, whereas varicella vaccine was licensed only for subcutaneous administration. This study evaluated the intramuscular administration of an MMR vaccine (M-M-RvaxPro) and a varic...

A low volume of bupivacaine has been recommended as a "test dose" before extradural injection of local anaesthetic in labour. In order to test the safety and efficacy of this test procedure, the effects of bupivacaine 1.6 ml given by extradural injection were compared with those following the same dose given by the intrathecal route. Various indices of motor, sensory and autonomic block were re...

as far as my memory goes, quinine by the intramuscular route was not only regarded as bad Practice, but was absolutely taboo, at least in the division in which I served. I can still remember the trepidation with which I administered quinine intramuscularly in 1917; I hoped that the brand of Cain, which I was certain must have glowed on my forehead, was not too visible to those who saw these per...

This study evaluated the effect of oral glucosamine and intramuscular injection (IM) of snail mucin on the progression of experimental osteoarthritis (OA) in dogs. Twenty adult mongrels with mean body weight (12.4±1.8 kg) were used. Experimental OA was induced surgically using the groove model. The dogs were randomly divided into three groups following radiographic evidence of OA. Group one (co...

PURPOSE Results for implantation efficiency and effective improvement of cardiac function in the field of mesenchymal stem cells (MSCs) are controversial. To attempt to clarify this debate, we utilized magnetic resonance imaging (MRI) and near-infrared optical imaging (OI) to explore the effects of different delivery modes of mesenchymal stem cells on cell retention time and cardiac function af...

OBJECTIVE: Social belief and experimental evidences indicate that opium and its alkaloids, morphine, produced hypoglycemic effects in animal models. This study was conducted in order to determine the role of morphine on blood glucose and insulin. MATERIAL AND METHODS: This is an empirical analysis investigating the laboratory albino male rats weighing 200-250 g. Rats in the control group recei...

The probability of faults occurring in the field increases with the evolution of the CMOS technologies. It becomes, therefore, increasingly important to analyze the potential consequences of such faults on the applications. Fault injection techniques have been used for years to validate the dependability level of circuits and systems, and approaches have been proposed to analyze very early in t...

Nesfatin-1 is an 82 amino acid peptide that suppresses food intake after intracerebroventricular injection. Nesfatin-1 and its precursor NUCB2 were identified by subtraction cloning in cell lines of both neuronal and adipocytic origin. This provides a strong basis for studies to determine how peripherally derived nesfatin-1 permeates the blood-brain barrier (BBB) to participate in its CNS actio...

introduction: estrogen and progesterone are supposed to modify pain sensitivity. however, the actual role of each of these steroid hormones in this respect is not well known. plasma concentrations of these hormones show variation during estrous cycle. the role of alpha2 receptors in tonic pain has been pointed out. the aim of the present study was to investigate the agonist and antagonist effec...