Celiac disease, a permanent, irreversible but treatable disease is an autoimmune triggered by gluten ingestion in genetically predisposed individuals, also known as celiac sprue and sensitive enteropathy. Recent findingsIntestinal inflammation villous atrophy small intestines permanent intolerance to disesea leads seveare malabsorption. About 20%-38% patients were basically nutritionally imbala...

Celiac disease is a chronic enteropathy and immune-mediated of the small intestine that affects about 1.1% to 1.7% world population. Presently effective medical treatment restriction gluten-containing foods. However, economic cost nutritional quality have negatively influenced maintenance gluten-free diet in several countries by consumers. In Brazil, scarcity information on these products point...

BACKGROUND In celiac disease patients, peptides derived from dietary gluten are recognized by HLA-DQ2-restricted CD4(+) T cells, which results in inflammation. Such immune-stimulatory peptides are found in both gliadins and glutenins. Monoclonal antibodies (mAbs) against these peptides can be used to screen food for the presence of such peptides. OBJECTIVE We aimed to determine the specificit...

A link between celiac disease and schizophrenia has been postulated for several years, based primarily on reports of elevated levels of antibody to gliadin in patients. We sought to examine the proposed connection between schizophrenia and celiac disease by characterizing the molecular specificity and mechanism of the anti-gliadin immune response in a subset of individuals with schizophrenia. B...

Adult celiac disease is a chronic intestinal disorder that has been estimated to affect up to 1-2% of the population in some nations. Awareness of the disease has increased, but still it remains markedly underdiagnosed. Celiac disease is a pathologically defined condition with several characteristic clinical scenarios that should lead the clinician to suspect its presence. Critical to diagnosis...

BACKGROUND Overexpression of autologous proteins can lead to the formation of autoantibodies and autoimmune diseases. MHC class I polypeptide-related sequence A (MICA) is highly expressed in the enterocytes of patients with celiac disease, which arises in response to gluten. The aim of this study was to investigate anti-MICA antibody formation in patients with celiac disease and its association...

Celiac disease has been associated with selective IgA immunoglobulin deficiency. A celiac disease cohort of 234 biopsy-defined adults (including 73 males and 161 females) from a 30-year period from 1982 to 2011 was reviewed. A total of 7 with selective IgA immunoglobulin deficiency were noted, or about 3%. All were female with an initial positive biopsy for untreated celiac disease. All had cha...

One of the diagnostic hallmarks of the histological lesions associated with celiac disease is the extensive infiltration of the small intestinal epithelium by CD8(+) T cells of unknown Ag specificity. In this study, we report recognition of the gliadin-derived peptide (A-gliadin 123-132) by CD8(+) T lymphocytes from celiac patients. A-gliadin 123-132-specific IFN-gamma production and cytotoxic ...

celiac disease (cd) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the hla dq2 or dq8 alleles. the etiology is multifactorial involving genetic and environmental factors, immune response, and intestinal dysbiosis. the innate and acquired t-cell mediated immunity play important roles in the pathogenesis of this disease, particular...