Gonorrhea may become untreatable due to the spread of resistant or multidrug-resistant strains. Cefixime-resistant gonococci belonging to sequence type 1407 have been described worldwide. We report the genome sequence of Neisseria gonorrhoeae strain G2891, a multidrug-resistant isolate of sequence type 1407, collected in Italy in 2013.

BACKGROUND/AIM Despite significant advances in current medicine and improvement of overall health education, chronic periodontitis is still a widespread disease. Losing teeth is the most serious complication of this particular illness. The aim of this study was to examine patients with chronic periodontitis in order to evaluate the efficacy of non-surgical therapy and combination of amoxicillin...

A convenient method for the preparation of alkynes and alkynyl esters from ketones and β-keto esters is described which involves the formation of vinyl triflates, followed by elimination with tetrabutylammonium fluoride trihydrate, to give alkynes. Unlike established elimination methods, the method requires neither a strong base nor anhydrous conditions.

Patients with purulent exacerbation of chronic bronchitis were randomized to receive either a single 400-mg daily dose of cefixime or 250 mg of cephalexin, orally, four times a day. Patients were males with a mean age of 63 years. Of the 86 patients, 71 (82%) had bronchitis caused by a single organism (29 by Haemophilus influenzae, 27 by Branhamella catarrhalis, 9 by gram-negative enteric organ...

Present study deals with two Spectrophotometric methods, Conventional Spectrophotometric Estimation and Area under Curve Method and a chromatographic method for estimation of Cefixime by using five different hydrotropic agents. These include Ammonium acetate (6M), Potassium acetate (5M), Potassium citrate (0.5 M), Sodium citrate (1.25 M) and Urea (8M). Area under curve method was based on measu...

Gonorrhea is a major cause of serious reproductive complications in women and can facilitate human immunodeficiency virus (HIV) transmission. Effective treatment is a cornerstone of U.S. gonorrhea control efforts, but treatment of gonorrhea has been complicated by the ability of Neisseria gonorrhoeae to develop antimicrobial resistance. This report, using data from CDC's Gonococcal Isolate Surv...

Neisseria gonorrhoeae has developed resistance to most of the available therapeutic antimicrobials. The susceptibility to extended-spectrum cephalosporins, the last remaining first-line treatment option, is decreasing globally. This report describes the first two cases outside Japan of verified gonorrhoea clinical failures using internationally recommended first-line cefixime treatment. Enhance...

To characterize and determine the quality of veterinary medicinal product «Amoxidev 60» (powder for oral use) which contains amoxicillin trihydrate, in addition to physical chemical tests, it is important develop a specification control input materials intended its production.
 The aim study was create drug based on trihydrate appropriate substantiate Veterinary «Amoxidev» - water-soluble ...

GONORRHEA HAS AFFECTED HUMANS FOR CENTUries and remains common. Worldwide, an estimated 106.1 million cases occur annually. In 2011, gonorrhea again was the second most commonly reported notifiable infection in the United States with 321 849 cases reported. Because gonorrhea often can be asymptomatic, the true disease burden may be closer to 700 000. Gonorrhea disproportionately affects racial,...

Cocrystallization of benzimidazole with benzene 1,3,5-tricarb-oxy-lic acid in slightly basic medium afforded the title compound, C(7)H(7)N(2) (+)·C(9)H(5)O(6) (-)·3H(2)O, in which one of the imidazole N atom is protonated and one carb-oxy-lic group of aromatic acid is deprotonated. In the crystal structure, inter-molecular N-H⋯O hydrogen-bonding connects the two organic components into dimers, ...