To the Editor: We read with great interest the article by Norden-Zfoni and colleagues in the May issue of Clinical Cancer Research. In this article, the investigators aimed to identify potential biomarkers in the blood of patients with metastatic gastrointestinal stromal tumors treated with sunitinib malate (Sutent, Pfizer, Inc.; ref. 1). One of these biomarkers was the number of circulating en...

Objective: We examined the clinicomorphologic factors associated with the lowand high-risk of generalization of cardioesophageal cancer (CEC) (T1-4N0-2M0) after complete (R0) esophagogastrectomies (EG) through left thoracoabdominal incision. Methods: We analyzed data of 175 consecutive CEC patients (CECP) (age = 55.3 ± 8.7 years; tumor size = 6.9 ± 3.3 cm) radically operated and monitored in 19...

The purpose of this paper is to introduce and provide context for the issues to be addressed at the North American Workshop on Risk Assessment and Children’s Environmental Health. It is not intended to be a comprehensive review of the current state of the science nor debate. This paper was prepared by the secretariat of the Commission on Environmental Cooperation (CEC). The views presented here...

A line of chick embryo cells (CEC) was obtained from CEC treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The cells, designated CHCC-OU2, were contact-inhibited, formed no colony in soft agar and did not produce tumors when inoculated into syngeneic chickens. The electron microscopic examination and reverse transcriptase assay showed no virus production from the cells. Subgroup A avian...

Cross-entropy clustering (CEC) is a density model based clustering algorithm. In this paper we present a possible application of CEC to the one-class classification, which has several advantage over classical approaches based on Expectation Maximization (EM) and Support Vector Machines (SVM). More precisely, we can use various types of gaussian models with lower computational complexity. We tes...

BACKGROUND All hospital trusts in Norway have clinical ethics committees (CEC). Some of them invite next of kin/patients to be present during the discussion of their case. This study looks closer at how parents of seriously ill children have experienced being involved in CEC discussions. METHODS Ten next of kin of six seriously ill children were interviewed. Their cases were discussed in two ...

Purpose We generate a renewable supply of corneal endothelial cells (CEC) from human pluripotent stem cells (PSCs) under defined culture conditions. Methods Corneal endothelial cell induction was driven by small molecules in a stepwise fashion of lineage specification. During the initial phase, PSC fate was restricted to the eye field-like state and became eye field stem cells (EFSCs). In the...

Ž Abstract: In this study, silica-based packing materials with pore sizes herein ̊ . referred to primarily as channel diameters, d ranging from 60 to 4000 A were ch utilized to elucidate the role of pore size in CEC. Separations were conducted using a commercially available CE system, the inlet and outlet buffer reservoir compartments having been modified to allow constant application of ;150 ps...

The dependence of regulatory volume decrease (RVD) activity on potassium-chloride cotransporter (KCC) isoform expression was characterized in corneal epithelial cells (CEC). During exposure to a 50% hypotonic challenge, the RVD response was larger in SV40-immortalized human CEC (HCEC) than in SV40-immortalized rabbit CEC (RCEC). A KCC inhibitor-[(dihydroindenyl)oxy] alkanoic acid (DIOA)-blocked...