نتایج جستجو برای: cdc42

تعداد نتایج: 3729  

2010
Anastasia Sacharidou Wonshill Koh Amber N. Stratman Anne M. Mayo Kevin E. Fisher George E. Davis

Here, we define an endothelial cell (EC) lumen signaling complex involving Cdc42, Par6b, Par3, junction adhesion molecule (Jam)–B and Jam-C, membrane type 1–matrix metalloproteinase (MT1-MMP), and integrin 2 1, which coassociate to control human EC tubulogenesis in 3D collagen matrices. Blockade of both Jam-B and Jam-C using antibodies, siRNA, or dominant-negative mutants completely interferes ...

Journal: :The Journal of Cell Biology 2004
Tatsuro Fukuhara Kazuya Shimizu Tomomi Kawakatsu Taihei Fukuyama Yukiko Minami Tomoyuki Honda Takashi Hoshino Tomohiro Yamada Hisakazu Ogita Masato Okada Yoshimi Takai

Nectins, Ca2+ -independent immunoglobulin-like cell-cell adhesion molecules, initiate cell-cell adhesion by their trans interactions and recruit cadherins to cooperatively form adherens junctions (AJs). In addition, the trans interactions of nectins induce the activation of Cdc42 and Rac small G proteins, which increases the velocity of the formation of AJs. We examined here how nectins induce ...

2017
Yongru Xu Yingzi Qi Jing Luo Jing Yang Qi Xie Chen Deng Na Su Wei Wei Deshun Shi Feng Xu Xiangping Li Ping Xu

Chronic hepatitis B virus (HBV) infection has been considered as the major cause of hepatocellular carcinoma (HCC). Hepatitis B virus X protein (HBx) has been reported to be oncogenic. The underlying mechanisms of HBV-related HCC are not fully understood, and the role played by the HBx protein in HBV induced carcinogenesis remains controversial. CDC42, a member of the Rho GTPase family, has bee...

2015
Lucas J.M. Bruurs Lisa Donker Susan Zwakenberg Fried J. Zwartkruis Harry Begthel A.S. Knisely George Posthuma Stan F.J. van de Graaf Coen C. Paulusma Johannes L. Bos

During yeast cell polarization localization of the small GTPase, cell division control protein 42 homologue (Cdc42) is clustered to ensure the formation of a single bud. Here we show that the disease-associated flippase ATPase class I type 8b member 1 (ATP8B1) enables Cdc42 clustering during enterocyte polarization. Loss of this regulation results in increased apical membrane size with scattere...

Journal: :Molecular biology of the cell 2007
Satoe Takahashi Peter M Pryciak

The Rho-type GTPase Cdc42 is a central regulator of eukaryotic cell polarity and signal transduction. In budding yeast, Cdc42 regulates polarity and mitogen-activated protein (MAP) kinase signaling in part through the PAK-family kinase Ste20. Activation of Ste20 requires a Cdc42/Rac interactive binding (CRIB) domain, which mediates its recruitment to membrane-associated Cdc42. Here, we identify...

2016
Patrick R. O’Neill Vani Kalyanaraman N. Gautam

Migratory immune cells use intracellular signaling networks to generate and orient spatially polarized responses to extracellular cues. The monomeric G protein Cdc42 is believed to play an important role in controlling the polarized responses, but it has been difficult to determine directly the consequences of localized Cdc42 activation within an immune cell. Here we used subcellular optogeneti...

Journal: :Blood 2012
Yosuke Harada Yoshihiko Tanaka Masao Terasawa Markus Pieczyk Katsuyoshi Habiro Tomoya Katakai Kyoko Hanawa-Suetsugu Mutsuko Kukimoto-Niino Tomoko Nishizaki Mikako Shirouzu Xuefeng Duan Takehito Uruno Akihiko Nishikimi Fumiyuki Sanematsu Shigeyuki Yokoyama Jens V Stein Tatsuo Kinashi Yoshinori Fukui

To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and follow the path of least resistance. It is known that this amoeboid migration of DCs requires Cdc42, yet the upstream regulators critical for localization and activation of Cdc42 remain to be determined. Mutations of DOCK8, a member of the at...

Journal: :Bioorganic & medicinal chemistry letters 2011
Brenda N Goguen Galen S Loving Barbara Imperiali

Cdc42, a member of the Rho GTPase family, is a fundamental regulator of the actin cytoskeleton during cell migration. To generate a sensor for Cdc42 activation, we employed a multi-pronged approach, utilizing cysteine labeling and expressed protein ligation, to incorporate the environment sensitive fluorophore 4-N,N-dimethylamino-1,8-naphthalimide (4-DMN) into the GTPase binding domain of the W...

2013
Aihua Hou Li Xian Toh Kah Hui Gan Khee Jin Ryan Lee Edward Manser Louis Tong

PURPOSE Epithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells to test their requirement in directional cell migration. METHODS Rho family small G-protein expression was assessed by reverse transcription-p...

2011
Ben Short

D rosophila may be small, but you can’t accuse them of lacking heart. Unless they’re missing the transcription factor Tinman, that is, in which case they fail to form a heart during embryogenesis (1, 2) or, if tinman is deleted later in development, they fail to maintain adult cardiac function (3). Qian et al. now reveal how Tinman works in conjunction with the small GTPase Cdc42 to regulate th...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید