نتایج جستجو برای: cdc25a
تعداد نتایج: 514 فیلتر نتایج به سال:
Sulforaphane modulates microRNA expression in colon cancer cells to 1 implicate the regulation of oncogenes CDC25A, HMGA2 and MYC. 2 Christopher A. Dacosta, Claudia Paicu, Irina Mohorianu, Wei Wang, Ping Xu, Tamas 3 Dalmay, Yongping Bao 4 Norwich Medical School, University of East Anglia, Norwich, NR4 7UQ, UK 5 School of Computing Sciences, University of East Anglia, Norwich, NR4 7TJ, UK 6 Scho...
Arylstibonates structurally resemble phosphotyrosine side chains in proteins and here we addressed the ability of such compounds to act as inhibitors of a panel of mammalian tyrosine and dual-specificity phosphatases. Two arylstibonates both possessing a carboxylate side chain were identified as potent inhibitors of the protein tyrosine phosphatase PTP-ß. In addition, they inhibited the dual-sp...
The ability to preserve genomic integrity is a fundamental feature of life. Recent findings regarding the molecular basis of the cell-cycle checkpoint responses of mammalian cells to genotoxic stress have converged into a two-wave concept of the G1 checkpoint, and shed light on the so-far elusive intra-S-phase checkpoint. Rapidly operating cascades that target the Cdc25A phosphatase appear cent...
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