Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising from the wall of the gastrointestinal tract with immunohistochemical reactivity for CD117 antibody, and usually prevalent in the fifth to seventh decade of life. The specific practical diagnostic criteria for GIST are c-kit expression (CD117), mitotic score, and the tumour size. The stomach is the most common site of lo...

BACKGROUND Gastrointestinal stromal tumours (GIST) usually present with non-specific gastrointestinal symptoms such as abdominal mass, pain, anorexia and bowel obstruction. METHODS We report a case of a 42 year old male who presented with a solitary intracranial space occupying lesion which was established as a metastasis from a mesenteric tumour. RESULTS The patient was initially treated a...

T cell development depends on continuous recruitment of progenitors from bone marrow (BM) to the thymus via peripheral blood. However, both phenotype and functional characteristics of physiological T cell precursors remain ill-defined. Here, we characterized a putative CD135(+)CD27(+) T cell progenitor population, which lacked expression of CD127, CD90, and high levels of CD117 and was therefor...

Molecular mechanisms underlying the pathophysiology of pemphigus vulgaris are still not clear. We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. Seventeen patients with active pemphigus vulgaris and 19 normal healthy controls were included in the study. The immu...

BACKGROUND Gastrointestinal stromal tumors (GISTs) rarely present with predominantly cystic changes. Here, we report a case of giant GIST of the stomach with predominantly cystic changes in a 74-year-old female patient. CASE PRESENTATION The tumor was 10 cm × 15 cm in size and positive for CD117, H-caldesmon, and DOG-1. Complete surgical resection was performed without regional lymphadenectom...

Introduction: Recently, there has been enormous progress in the diagnosis and treatment of multiple myeloma (MM). Despite importance flow cytometry cytogenetic, biomarkers are being sought to assess prognosis response treatment. The aim this study was determine significance histological evaluation immunohistochemical markers MM patients. Material methods: A retrospective analysis performed 90 b...

Human skeletal muscle tissue displays specific cellular architecture easily damaged during individual existence, requiring multiple resources for regeneration. Congruent with local prerequisites, heterogeneous muscle stem cells (MuSCs) are present in the muscle interstitium. In this study, we aimed to characterize the properties of human muscle interstitial cells that had the characteristic mor...