CD4 T helper cells are well known for their role in providing critical signals during priming of cytotoxic CD8 T lymphocyte (CTL) responses in vivo. T-cell help is required for the generation of primary CTL responses as well as in promoting protective CD8 memory T-cell development. However, the role of CD4 help in the control of CTL responses at the effector stage is unknown. Here we show that ...

Design and Methods. Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2×106, 1×107 and 5×107 CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1×107 and 5×107 CD3+ ce...

clinical utility. device's resource-limited settings. Nevertheless, more testing on patients over time will be necessary to determine the and costing less per test than certain flow cytometers, it is possible that this device will be useful in −− analysis sample preparation, purification, and −− complete picture of infection. By integrating all steps of POC detection Unique to this device is th...

OBJECTIVES To study the effect of an individualized treatment approach with regard to dosage intervals between infliximab infusions on the clinical outcome of pediatric Crohn's disease (CD). PATIENTS AND METHODS A retrospective analysis of medical records of all pediatric patients with CD who had been treated with infliximab between 1999 and 2007 in two Swedish counties, where an individualiz...

posed of a-1,4-linked glucose units, and a-, band g-CD, which are composed of 6, 7 and 8 glucose units, have been well studied and used in various fields because of their inclusion complex formation ability. However, their cavities are too small to form inclusion complexes with large guest molecules with molecular weights higher than several hundred. Large-ring CDs (LR-CDs) composed of more tha...

Castleman disease (CD) is a nonclonal lymphoproliferative disorder that can affect single lymph node stations or, alternatively, can be generalized. Interleukin 6 (IL6) plays a pivotal role in the pathophysiology of CD. Human herpesvirus 8 (HHV8), which encodes a viral homolog of IL6, is the driving force in HIV-positive patients. The role of HHV8 in HIV-negative CD is controversial. Historical...

Effective enantiomeric separations of erythro- and threo-8.O.4'-neolignans with different aromatic substitution pattern (1a-i, 2a-i) are achieved on the commercially available chiral stationary phase cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD). It is shown that the chiral recognition of the stationary phase is significantly dependent on the substitution pattern of the racemic com...