Unmethylated CpG oligodeoxynucleotides induce inflammatory immune responses through cytokine production and have attracted increasing attention as an immunostimulator. However, there remains a challenging issue of the use of 'native CpG DNA'. In the present study, we prepared cationic nanometer-sized gels (nanogels) consisting of cycloamylose modified with cholesterol and diethylaminoethane to ...

Cationic polypeptides interact with bacterial cells of E. coli and B. anthracis. They confer upon the cells some of the characteristics of cationic particles. Since bacterial cells usually behave as anions, acidic dyes at high pH levels differentiate between cells which have and those which have not interacted with cationic polypeptides. Under the conditions of these experiments it appeared tha...

In this study a cationic talc was applied to deinked pulp for control of sticky contaminants. Effects of the cationic talc on stickies and dissolved and colloid substances were investigated and compared with those of a conventional talc. Characteristics of wet-end chemistry were examined for the pulp with addition of both kinds of talc samples. Furthermore, influences on paper properties were a...

A vaccine strategy directed to increase Th1 cellular immune responses, particularly to hepatitis C virus (HCV) nonstructural protein 3 (NS3), has considerable potential to overcome the infection with HCV. DNA vaccination can induce both humoral and cellular immune responses, but it became apparent that the cellular uptake of naked DNA injected into muscle was not very efficient, as much of the ...

the pollution of water environments is a challenging issue especially in developing countries. contamination of drinking water with heavy metals has been reported in many parts of the world. arsenic, chromium and lead are dangerous heavy metals and also common contaminants of drinking water. in this study, the capacity and performance of the surfactant-modified sabzevar natural nanozeolite (sms...

a novel quaternary ammonium-based cationic gemini surfactant (s6) having 1,6 di-bromo hexane as a spacer, have been used and its interaction with insulin in aqueous solution (ph, 7.40) was investigated by several methods including fluorescence spectroscopy, uv-vis spectroscopy, circular dichroism, dynamic light scattering, ζ-potential measurements, conductivity and transmission electron microsc...

In this review, we report some recent advances and new horizons in UV-induced cationic photopolymerization. In particular, after a brief introduction on the discovery and affirmation of the cationic photopolymerization process, new efforts in the synthesis of cationic photoinitiators are reported. Subsequently, an interesting and absolutely new application is reported, related to the combinatio...

Different viral and non-viral vectors have been designed to allow the delivery of nucleic acids in gene therapy. In general, non-viral vectors have been associated with increased safety for in vivo use; however, issues regarding their efficacy, toxicity and stability continue to drive further research. Thus, the aim of this study was to evaluate the potential use of the polymerizable diacetylen...

Interaction studies between a set of poly(ethylene glycol) (PEG) based cationic bottle-brush block copolymers (BBCPs) and calf thymus DNA (ctDNA) were carried out using steady state fluorescence spectroscopy, UV melting experiments and dynamic light scattering measurements. Results suggested that these cationic block copolymers could effectively bind with negatively charged DNA. Although electr...

Human cationic trypsinogen is activated by human enteropeptidase much more readily than bovine trypsinogen, the ratios k,,,/K,,, being 330 and 11 mr+-’ s’, respectively. Conversely, porcine enteropeptidase activates bovine trypsinoyen much more rapidly (k&K,,, = 630 rnM-‘s-‘) than human cationic trypsinogen (k,,,/K,,, = 2.4 mM-‘s--‘). The primary structure of the activation region of human cati...