نتایج جستجو برای: catecholamine
تعداد نتایج: 7533 فیلتر نتایج به سال:
UNLABELLED Neurophysiological evidence suggests that neuromodulators, such as norepinephrine and dopamine, increase neural gain in target brain areas. Computational models and prominent theoretical frameworks indicate that this should enhance the precision of neural representations, but direct empirical evidence for this hypothesis is lacking. In two functional MRI studies, we examine the effec...
Dinh, Thu T., Francis W. Flynn, and Sue Ritter. Hypotensive hypovolemia and hypoglycemia activate different hindbrain catecholamine neurons with projections to the hypothalamus. Am J Physiol Regul Integr Comp Physiol 291: R870–R879, 2006. First published May 4, 2006; doi:10.1152/ajpregu.00094.2006.—To better understand the involvement of hindbrain catecholamine neurons in hypovolemia-induced se...
The biological presence and regulatory function of the plant alkaloid morphine in relatively simple and complex integrated animal systems has previously been shown. The pivotal role of dopamine as a chemical intermediate in the morphine biosynthetic pathway in plants establishes a functional basis for its expansion into an essential role as the progenitor catecholamine signaling molecule. In in...
Sympathetic neurons taken from rat superior cervical ganglia and grown in culture acquire cholinergic function under certain conditions. These cholinergic sympathetic neurons, however, retain a number of adrenergic properties, including the enzymes involved in the synthesis of norepinephrine (NE) and the storage of measurable amounts of NE. These neurons also retain a high affinity uptake syste...
BACKGROUND Prior research has connected posttraumatic stress disorder (PTSD) to increased levels of catecholamines. However, studies of cortisol levels have produced mixed results. OBJECTIVE To examine urinary catecholamine and cortisol levels in individuals with PTSD in a community sample. DESIGN A representative cohort of young adult community residents, assessed periodically during a 10-...
Portbury, Andrea L., Rashmi Chandra, Marybeth Groelle, Michael K. McMillian, Alana Elias, James R. Herlong, Maribel Rios, Suzanne Roffler-Tarlov, and Dona M. Chikaraishi. Catecholamines act via a -adrenergic receptor to maintain fetal heart rate and survival. Am J Physiol Heart Circ Physiol 284: H2069–H2077, 2003. First published February 6, 2003; 10.1152/ajpheart.00588.2002.— Mice lacking cate...
Digitonin permeabilizes the plasma membranes of bovine chromaffin cells to Ca2+, ATP, and proteins and allows micromolar Ca2+ in the medium to stimulate directly catecholamine secretion. In the present study the effects of digitonin (20 microM) on the plasma membrane and on intracellular chromaffin granules were further characterized. Cells with surface membrane labeled with [3H]galactosyl moie...
Cardiac hemodynamic studies during control resting state and isoproterenol infusion were performed on five patients with constrictive pericarditis. During isoproterenol infusion, stroke volume increased by 60%, while there was no significant change in pulmonary wedge and right atrial mean pressures. The relatively fixed filling pressure is the indirect evidence of fixed diastolic size of the he...
The regulation of the intermediary steps of the catecholamine-stimulated GTPase cycle by &adrenergic agonists and Mg2+ was investigated using unilamellar phosphatidylethanolaminephosphatidylserine vesicles that contained purified &adrenergic receptor and the stimulatory GTP-binding protein of the adenylate cyclase system, G. The steady-state turnover number of the agonist-stimulated GTPase, nor...
Abstract Purpose Post cardiac surgery hypotension and inotrope dependence are among major causes of prolonged intensive care unit (ICU) stay. Besides routine managements, catecholamine inotrope-vasopressors the traditional treatment. However, there is an increasing interest to catecholamine-sparing agents, such as Midodrine, oral alfa1 agonist, in patients with vasoplegia. Up now no randomized ...
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