In the rostral ventrolateral medulla (RVLM), angiotensin II-derived superoxide anions, which increase sympathetic nerve activity, induce a pressor response by activating the p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK) pathway. The small G protein Ras mediates a caspase-3-dependent apoptotic pathway through p38 MAPK, ERK, and c-Jun N-terminal k...

Hexameric hemoprotein (HTHP) is employed as a scaffold protein for the supramolecular assembly and activation of apoptotic signalling enzyme caspase-9, using short DNA elements modular recruitment domains. Caspase-9 on HTHP platform due to enhanced proximity followed by combinatorial inhibition at high concentrations. The domains allow reversible switching caspase-9 activity state modulatory st...

Sedum middendorffianum Maxim (SMM) is a Korean endemic plant belonging to the Crassulaceae family. This study aimed investigate antitumor effects of SMM extract on human ovarian cancer cells. Among five plants grown in Korea, showed most potent cytotoxicity cells and had little effect normal surface epithelial Furthermore, we revealed that dose-dependently induced apoptosis A2780 SKOV3 The mark...

background: it is well known that the hippocampus, the ca1 pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. recently, it is observed that pentoxifylline has a neuroprotective effect. this study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the p...

introduction: ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. the purpose of this study was investigating the effects of exercise preconditioning on expression of bax, bcl-2, and caspase-3 proteins in hippocampal ca1 neurons after induction of cerebral ischemia. methods: male rats weighing 260-300 g were randomly allocated into three grou...

The purpose of this study was to examine the effects of 28-days of supplementation with an aqueous proprietary polyphenol blend (PPB) sourced from Camellia sinensis on intramuscular apoptotic signaling following an acute lower-body resistance exercise protocol and subsequent recovery. Untrained males (n = 38, 21.8 ± 2.7 years, 173.4 ± 7.9 cm, 77.6 ± 14.6 kg) were randomized to PPB (n = 14), pla...