Cocaine and amphetamine regulated transcript (CART) encodes a novel brain-enriched protein whose features are reminiscent of a neurotransmitter propeptide. We have now localized CART peptide(s) in the gastrointestinal tract by immunohistochemical methods. Polyclonal antisera raised to CART peptide 106-129 stained neuronal cell bodies and fibers in rat ileum myenteric plexus-longitudinal muscle ...

This paper relates to the construction and testing of a solarpowered golf cart and the future incorporation of a fuel cell system to the existing solar cart. The prototype built in 2004 [fig 1] proved to be very successful. The combination of unique features such as the tracking of the sun resulted in the increase of output power with respect to other solar carts. In addition, the cart turns in...

CART peptides are endogenous neurotransmitters that are involved in a variety of physiologic functions. Injection of CART 55-102 into the nucleus accumbens produces no effect, but when co-administered with cocaine, it reduces the locomotor and rewarding properties of cocaine. In a human study, subjects carrying a missense mutation of the CART gene exhibited increased anxiety and depression. Als...

Cocaine- and amphetamine-regulated transcript (CART) is a recently discovered hypothalamic peptide regulated by leptin and with a potent appetite-suppressing activity. In the rat, the CART gene encodes a peptide of 116 amino acid residues (or a splice variant 13 residues longer). The predicted signal sequence is 27 amino acid residues, resulting in a prohormone of 89 residues. The CART prohormo...

The AdaBoost like algorithm for boosting CART regression trees is considered. The boosting predictors sequence is analyzed on various data sets and the behaviour of the algorithm is investigated. An instability index of a given estimation method with respect to some training sample is defined. Based on the bagging algorithm, this instability index is then extended to quantify the additional ins...

OBJECTIVE The cocaine- and amphetamine-regulated transcript (CART) codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART function, as discrepant effects of central CART administration have been reported. METHODS By combining Cart-cre knock-in mice with a Cart adeno-asso...

Exogenous cytokines are widely applied to enhance the anti-tumor ability of immune cells. However, systematic comparative studies of their effects on chimeric antigen receptor (CAR)-engineered T (CART) cells are lacking. In this study, CART cells targeting folate receptor-alpha were generated and expanded ex vivo in the presence of different cytokines (IL-2, IL-7, IL-15, IL-18, and IL-21), and ...

Complementary DNAs encoding two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors were identified from goldfish brain and named CART I and CART II. Each cDNA contains a signal peptide sequence, the putative CART-like peptide, and a carboxy-terminal extension peptide. Form I encodes a 117-amino acid pro-CART, whereas form II encodes a 120-amino acid pro-CART. Both ...

High-resolution remote-sensing images can be used in human activity analysis and criminal monitoring, especially sparsely populated zones. In this paper, we explore the applicability of China’s Gaofen satellite land cover classification Xinjiang, China. First all, features spectral reflectance a normalized radar cross section (NRCS) for different types covers were analyzed. Moreover, seasonal v...