Bean common mosaic virus from the genus Potyvirus has a wide range of hosts and very negative impact on cultivated crops Phaseolus. The risk viral infection economically important increases even if carriers are related plant species growing agroecological interfaces. Such have emerged as new for BCMV, usually harboring novel genetic variants virus. A variant BCMV was isolated symptomatic crownv...

Abstract The members of the mitochondrial carrier family, also known as solute family 25 (SLC25), are transmembrane proteins involved in translocation a plethora small molecules between intermembrane space and matrix. These transporters characterized by three homologous domains structure transport mechanism that involves transition different conformations. Mutations regions critical for these t...

Abstract Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ER? enhances ER?-induced transcription activity. Tripartite motif-containing (TRIM) proteins are new class SUMO E3 ligases, which regulate the proteins. However, precise molecular mechanism and function TRIM3 response to tamoxifen remain unclear. In present study, we observe...

The monomeric cupredoxins are a highly divergent family of copper binding electron transport proteins that function in photosynthesis and respiration. To determine how function and structure are conserved in the context of large sequence differences, we have carried out a detailed analysis of the cupredoxins of known structure and their sequence homologs. The common structure of the cupredoxins...

This paper presents the development and application of graph neural networks to verify drug interactions, consisting drug-protein networks. For this, DrugBank databases were used, creating four complex interactions: target proteins, transport carrier enzymes. The Louvain Girvan-Newman community detection algorithms used establish communities validate interactions between them. Positive results ...

background: candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. it is speculated that structural and secretory proteins of c. albicans have immunomodulatory effects in cancer. objective: to evaluate the effects of c. albicans structural and secreted proteins on intratumoral cd4/cd8 ratio as well as the survival rate in balb/c t...