Developing clinical work suggests that vascular stiffening plays a role in the progression of pulmonary hypertension (PH), while recent studies in animal models of hypoxic PH have found significant proximal vascular stiffening in the diseased population. Here, we develop and validate a minimally invasive, clinically realizable method to estimate the local elastic modulus of the proximal pulmona...

Disordered filamentous networks with compliant crosslinks exhibit a low linear elastic shear modulus at small strains, but stiffen dramatically at high strains. Experiments have shown that the elastic modulus can increase by up to three orders of magnitude while the networks withstand relatively large stresses without rupturing. Here, we perform an analytical and numerical study on model networ...

Key elastic properties of full-sized wood composite panels (WCPs) must be accurately determined not only for safety, but also serviceability demands. In this study, the modal parameters of full-sized WCPs supported on four nodes were analyzed for determining the modulus of elasticity (E) in both major and minor axes, as well as the in-plane shear modulus of panels by using a vibration testing m...

We study the elastic properties of a two-dimensional fluctuating surface whose area density is allowed to deviate from its optimal (Schulman) value. The behavior of such a surface is determined by an interplay between the area-dependent elastic energy, the curvature elasticity, and the entropy. We identify three different elastic regimes depending on the ratio Ap/As between the projected (frame...

The deformation and mechanical behavior of individual zeolitic-imidazolate framework (ZIF-8) micro- and sub-microcrystals were observed under compression. Young's modulus and volume changes as a function of applied pressure were determined on individual single crystals, offering insights in the relationship among structure, morphology, and mechanical properties. Dramatic volume decreases and am...

A wave traveling upward through a particle bed is observed to steepen and form a shock as the surface is approached. This steepening is due to the increase in the local speed of sound that is induced by the local pressure increase in the upward moving phase of the wave behind the wave front. The pressure increase leads to an increase in the local coordination number which in turn increases the ...

In order to investigate the effect of applied stress on mechanical properties in metallic glasses, nanoindentation tests were conducted on elastically bent Zr-Cu-Ag-Al metallic glasses with two different structure states. From spherical P-h curves, elastic modulus was found to be independent on applied stress. Hardness decreased by ~8% and ~14% with the application of 1.5% tensile strain for as...

Advances in our ability to assess fracture risk, predict implant success, and evaluate new therapies for bone metabolic and remodeling disorders depend on our understanding of anatomically specific measures of local tissue mechanical properties near and surrounding bone cells. Using nanoindentation, we have quantified elastic modulus and hardness of human lamellar bone tissue as a function of t...