Autonomic cardiovascular control was characterized in conscious, chronically catheterized mice by spectral analysis of arterial pressure (AP) and heart rate (HR) during autonomic blockade or baroreflex modulation of autonomic tone. Both spectra were similar to those obtained in humans, but at approximately 10x higher frequencies. The 1/f relation of the AP spectrum changed to a more shallow slo...

Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality. These high-risk, multi-morbid patient populations benefit less from currently available anti-hypertensive treatment. Simultaneous angiotensin II type 1 receptor blockade and neprilysin inhibition ('ARNI') with valsartan/sacubitril (LC...

The overall objectives of this workshop were (i) to identify physiological mechanisms involved in short-term cardiovascular-respiratory regulation, (ii) to develop mathematical models to improve understanding, diagnosis, and treatment of clinical problems related to short-term cardiovascular-respiratory regulation, (iii) to discuss the methodological and computational framework for adapting com...

Model of the cardiovascular system is mechanical simulator of the haemodynamic parameters of the human bloodstream. It is a system of pipes, valves, pump and other additional elements. The system is designed to imitate the flow of blood in a healthy human body. In the final model there are measured basic haemodynamic parameters such as blood pressure, cardiac output, pulse wave velocity and mor...

Acute cardiovascular exercise effects on cognitive function were examined using an executive control task by comparing neuroelectric and behavioral performance at baseline with post-exercise in 20 undergraduates. A within-subjects design was used to assess the P3 component of an event-related brain potential (ERP) and behavioral performance using a task that varied the amount of executive contr...

Central serotonergic neurones control reflex parasympathetic outflow to the heart, airways and bladder in a number of species, and different 5-HT receptor subtypes are involved in this effect. 5-HTja and 5 -HT3 receptors in the brainstem facilitate these reflexes, whilst 5-HTjb/id, 5-HT2 and 5 -HT4 receptors inhibit them. Recently, central 5 -HT7 receptors have been implicated in bladder reflex...

Cardiovascular function is regulated by a dynamic balance comprised of sympathetic and parasympathetic influences. Sympathetic regulatory centers include the rostra ventrolateral medulla (RVLM) and paraventricular nucleus of hypothalamus (PVN). Pre-sympathetic neurons (PSNs) in these centers project directly to sympathetic preganglionic neurons in the intermediolateral nucleus of the thoracic s...