background: muscle fibers overlying the intramyocardial segment of an epicardial coronary artery are termed myocardial bridge (mb). the aim of this study was to analyze the mid-term outcome of mb and to examine its possible association with angiographic findings and concomitant cardiac pathologies such as hypertrophic cardiomyopathy (hcm).   methods: from a total of 3218 patients admitted for c...

The assay of serum enzymes is very useful for the differential diagnosis and monitoring various hepatobiliary disorders. Aspartate aminotransferases are found in liver, cardiac muscle, skeletal kidneys, brain, pancreas, lungs, leukocytes, erythrocytes decreasing order concentration. Alanine muscle (cardiac skeletal), these specific indicators hepatocellular injury dogs cats not large animals pi...

For the purpose of examining the effect of the elective cardiac arrest on the heart muscle, the isolated Langendorf dog's heart preparation with cross circulation was prepared for analysis of the physiological and histological reaction of the cardiac muscle induced by 30 minutes coronary occlusion with or without cardiac arrest. As the heart muscle is loaded with anoxia during cardiac arrest, g...

We have shown in genetic myopathic hamsters that cardiac myofibrillar ATPase regulation by calcium is altered and that there are shifts in myosin isozyme distribution (V1----V3) suggesting abnormalities in multiple components of the contractile apparatus. To focus more on the regulatory proteins (troponin and tropomyosin), individual proteins of the skeletal and cardiac actomyosin system were r...

Obesity and diabetes are associated with increased fatty acid availability in excess of muscle fatty acid oxidation capacity. This mismatch is implicated in the pathogenesis of cardiac contractile dysfunction and also in the development of skeletal-muscle insulin resistance. We tested the hypothesis that 'Western' and high fat diets differentially cause maladaptation of cardiac- and skeletal-mu...

Quinidine potentiates twitch tension and (at higher concentrations) causes contracture of skeletal muscle whereas the same drug reduces tension development of cardiac muscle. To gain insight into the possible differences in the excitation-contraction coupling mechanism of the two types of muscle the effect of quinidine on calcium accumulation by isolated sarcoplasmic reticulum from skeletal and...

Healthy living throughout the lifespan requires continual growth and repair of cardiac, smooth, and skeletal muscle. To effectively maintain these processes muscle cells detect extracellular stress signals and efficiently transmit them to activate appropriate intracellular transcriptional programs. The striated muscle activator of Rho signaling (STARS) protein, also known as Myocyte Stress-1 (M...

Ischemic cardiac disease is a condition caused by disordered balance between thecoronary blood-flow and the metabolic needs of cardiac muscle. Thus the imbalance between cardiac musсle’s (myocardium) oxygen needs and its delivery leads to the cardiac muscle’s oxygen starvation (myocardial hypoxia) and to accumulation of toxic metabolism products in the myocardium causing the pain. The main reas...

during isometric contraction. J Physiol (Lond) 251: 627-643 Krueger JW, Wittenberg BA (1978) Dynamics of myofilament sliding in single intact cardiac muscle cells (abstr). Circulation 58: (suppl II): 33 Lapicque L (1907) Recherches quantitative sur l'excitation electriquer des nerfs traitee comme une polarisation. J Physiol (Paris) 9: 620-635 Manring A, Nassar R, Johnson EA (1977) Light diffrac...

Calcium (Ca(2+)) signaling plays a key role in a wide range of physiological functions including control of cardiac and skeletal muscle performance. To assure a precise coordination of both temporally and spatially transduction of intracellular Ca(2+) oscillations to downstream signaling networks and target operations, Ca(2+) cycling regulation in muscle tissue is conducted by a plethora of div...