We tested the hypothesis that melatonin prevents brain death (BD) tissue extract (BDEX)-induced cardiac damage by suppressing inflammatory damage-associated molecular pattern (DAMP) signaling in rats. Six hours after BD induction, levels of a DAMP component (HMGB1) and inflammatory markers (TLR-2, TLR-4, MYD88, IκB, NF-κB, IL-1β, IFN-γ, TNF-α and IL-6) were higher in brain tissue from BD animal...

Anthracycline-containing chemotherapy (eg, doxorubicin) is well known to cause dose-dependent, progressive cardiac damage clinically manifest as decreased left ventricular (LV) ejection fraction and, ultimately, heart failure (HF) (Table 1).1,2 Unfortunately, the only clinically accepted method to minimize injury is dose modification and/or therapy discontinuation.3 An important current challen...

Prolonged exercise has been shown to result in an acute depression in cardiac function. However, little is known about the effect of this type of exercise on vascular function. Therefore, the purpose of the present study was to investigate the impact of an acute bout of prolonged strenuous exercise on vascular and cardiac function and the appearance of biomarkers of cardiomyocyte damage in 15 m...

BACKGROUND Remote ischemic preconditioning (RIPC) is the process of inducing brief ischemia in a tissue to prevent ischemic damage in another. This preconditioning can be induced simply by inflating a blood pressure cuff on a limb. Previous randomized controlled trials (RCT) have suggested that RIPC may infer myocardial protection during open cardiac surgery. One method of assessing the degree ...

Aims Mechanical chest compression (CC) during cardiopulmonary resuscitation (CPR) with AutoPulse or LUCAS devices has not improved survival from cardiac arrest. Cohort studies suggest risk of excess damage. We studied safety of mechanical CC and determined possible excess damage compared with manual CC. Methods and results This is a randomized non-inferiority safety study. Randomization to Au...

Cardiac arrest induces the cessation of cerebral blood flow, which can result in brain damage. The primary intervention to salvage the brain under such a pathological condition is to restore the cerebral blood flow to the ischemic region. Ischemia is defined as a reduction in blood flow to a level that is sufficient to alter normal cellular function. Brain tissue is highly sensitive to ischemia...

Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a h...

patients and methods this retrospective study used a database of a cr ward of a hospital in iran. the demographic and clinical information of 574 patients participating in the cr program from april 2005 through april 2010 were analyzed. in order to determine the predictors of anxiety, binary logistic regression was performed. results after adjustment for gender, age and education, the results s...

More than 110 years after Chagas disease discovery, some aspects of the mechanisms involved in physiopathology heart damage are still unknown. Previously, Trypanosoma cruzi was considered to be only cause myocardial injury. Currently, there other known disease, including immune-inflammatory response, autoimmunity, microvascular abnormalities and nerve damage, which interrelated contribute cardi...

objective: tilmicosin (til) is a long-acting macrolide antibiotic used to treat cattle for pathogens that cause bovine respiratory disease. however, overdoses of this medication have been reported to induce cardiac damage. our experimental objective was to evaluate the protective effects of spirulina platensis (sp) administration against til-induced cardiotoxicity in mice. materials and methods...