Amplitudes of cardiac contractions initiated by Ca2+-induced Ca2+ release (CICR) are proportional to the magnitude of Ca2+ current (ICa-L). However, large contractions accompanied by little inward current have been reported in some but not all studies in which cells were dialyzed with different analogs of cAMP. This study compares the effects of different phosphodiesterase (PDE)-resistant and P...

A new tinnitus syndrome is described: high-pitched, cardiac-synchronous tinnitus, whose pulsations are suppressed by strong contractions or compressions of the neck and jaw muscles (somatic testing). 14 cases, 6 non-lateralized and 8 unilateral, are reported. In the non-lateralized cases, onset was bilateral. In the one intermittent case, while her tinnitus was absent her pulsatile tinnitus cou...

Introduction Cardiac arrhythmias, whether ventricular or supraventricular, initially presented a challenge for coronary computed tomography angiography (CCTA) because they could result in motion artifact during image acquisition, increased acquisition times, and increased radiation dose. Cardiac motion and misregistration artifacts in a scan performed during premature ventricular contractions c...

The Drosophila heart has gained considerable traction as a model of cardiac development and physiology. Previously we described a semiautomatic optical heartbeat analysis (SOHA) method for quantifying functional parameters from the fly heart that facilitated its use as an organ system and disease model. Here we present an extensively rewritten version of the original SOHA program that takes adv...

Circulation. 2017;135:808–811. DOI: 10.1161/CIRCULATIONAHA.116.026903 808 ECG CHALLENGE A 59-year-old man presented to our hospital reporting 3 months of exertional dyspnea, ortopnea, paroxysmal nocturnal dyspnea, and lower leg edema. On physical examination, he had jugular venous distention, bibasilar rales, large tender liver, and peripheral edema. On cardiac auscultation, he had a regular he...

The mammalian heartbeat is thought to begin just prior to the linear heart tube stage of development. How the initial contractions are established and the downstream consequences of the earliest contractile function on cardiac differentiation and morphogenesis have not been described. Using high-resolution live imaging of mouse embryos, we observed randomly distributed spontaneous asynchronous ...

recently, zhang and song [q. zhang, y. song, fixed point theory forgeneralized $varphi$-weak contractions,appl. math. lett. 22(2009) 75-78] proved a common fixed point theorem for two mapssatisfying generalized $varphi$-weak contractions. in this paper, we prove a common fixed point theorem fora family of compatible maps. in fact, a new generalization of zhangand song's theorem is given.