BACKGROUND: Carcinoid tumors are the most frequently encountered endocrine tumors of the gastrointestinal tract. They are most often found in the appendix, although they can arise in any location of the gut. Carcinoid tumors may secrete a variety of bioactive substances, which can cause the complex of symptoms associated with the carcinoid syndrome. METHODS: The authors reviewed the pathology, ...

Neuroendocrine neoplasms of the larynx encompass five separate tumors: paraganglioma, typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. Many synonyms are employed, with well-, moderately, and poorly differentiated neuroendocrine carcinoma commonly applied to the middle three tumors (World Health Organization preferred terminology). Paraganglio...

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Malignant transformation of mature cystic teratoma is uncommon , and occurs in approximatel...

OBJECTIVES To describe a rare case of primary carcinoid tumor of the liver and its management. CLINICAL PRESENTATION AND INTERVENTIONS A 44-year-old Nigerian male presented with a big inoperable liver mass, which proved to be a carcinoid tumor by fine needle aspiration cytology. Extensive search for a primary lesion including laparotomy and peroperative ultrasound failed to find a primary les...

A 56-years-old man with a small rectal carcinoid tumor without carcinoid syndrome was admitted at Chareongkrung Pracharak Hospital with rectal bleeding. Proctoscopy revealed a small 7-mm rectal polyp, at 6 cm above the dentate line. Histology was diagnostic of a carcinoid tumor without atypical histopathologic feature or invasion into the muscularis propria . Immunohistochemical study was posit...

The recent WHO Classification of Tumours of the Digestive System reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, 10 December 2009 [1]. In this classification, the “neuroendocrine neoplasms of the small intestine” include neuroendocrine tumor (NET), neuroendocrine carcinoma (NEC), mixed...

Background: Carcinoid tumors rarely arise in the extrahepatic bile duct and can be difficult to distinguish from carcinoma. There are no reports of clear cell carcinoid (CCC) tumors in the distal bile duct (DBD) to the best of our knowledge. Herein, we report a CCC tumor in the DBD and review the literature concerning extrahepatic bile duct carcinoid tumors. Case presentation: A 73-old man pres...

PURPOSE The use of replication-selective oncolytic adenoviruses is an emerging therapeutic approach for cancer, which thus far has not been employed for carcinoids. We therefore constructed Ad[CgA-E1A], a novel replication-selective oncolytic adenovirus, where the chromogranin A (CgA) promoter controls expression of the adenoviral E1A gene. EXPERIMENTAL DESIGN The Ad[CgA-E1A] virus was evalua...

Carcinoid tumor of the thymus is a rare neoplasm. It comprises a wide spectrum of lesions ranging from well-differentiated to poorly-differentiated neoplasms. We report a case of anterior mediastinal mass, which is proven to be an atypical thymic carcinoid tumor with a histopathological nature of intermediate-grade moderately-differentiated neuroendocrine carcinoma. We also present the patient’...