The synthesis of some fluorescent coumarin dyes derived from coumarin-3-carboxylic acid were described.The new dyes are obtained by condensation of coumarin – 3 carboxylic acid derivatives with para substituted ortho phenylenediamines and cyclisation of the mono condensed ortho phenylenediamines in an acid medium. The obtained dyes were characterized from their physico-chemical point of view by...

Silver complexes with 5-(4-(tert-butyl)-1H-imidazol-1-yl)-imidazo[1,5-a]pyridin-3-ylidene ligands were synthesized as metal-imidazole acid-base cooperative catalysts. Single crystal XRD analysis revealed that the silver atom was located in vicinity of imidazole ring and cationic formed dimers through coordination between metal pendant. These served catalysts for cyclization alkyne-tethered carb...

We report here the first study of the protonated, neutral form of tetrazoles as anion binding functional groups. Our studies reveal them to be capable of binding anions with extremely high potency in polar solutions. In studying carboxylic acid-containing congeners, we find a remarkable discrepancy: a strictly analogous acid-containing host binds anions > or = 50,000-fold more weakly than the t...

UNLABELLED L-cysteine is essential for virtually all living organisms, from bacteria to higher eukaryotes. Besides having a role in the synthesis of virtually all proteins and of taurine, cysteamine, glutathione, and other redox-regulating proteins, L-cysteine has important functions under anaerobic/microaerophilic conditions. In anaerobic or microaerophilic protozoan parasites, such as Entamoe...

choline oxidase (chox) was chosen as a model enzyme for evaluating the performance of cnts’ functional groups for development of enzyme electrodes. cnts were functionalized with carboxylic acid, amine or amide groups. carboxylic acid, amine and amide functionalized cnts were obtained by acid treatment, ethylenediamine or tetraethylenepentamine chemically modification and ammonia plasma treatmen...

As reported in our previous paperslf2), (3R,4R, 5#,6#)-6-(trifluoroacetamido)-3,4,5-trihydroxypiperidine-3-carboxylic acid (tentatively named SF 1 ) and (35,4S',5K,6^)-6-(trifluoroacetamido)-4, 5-dihydroxypiperidine-3-carboxylic acid (SF4) which were synthesized as trifluoroacetamide analogues of siastatin B3) (Fig. 1), were highly inhibitory against /?-glucuronidase (EC 3.2.1.31) from bovine l...

The results of studying the physical properties a deep eutectic solvent based on choline chloride and sulfosalicylic acid have been presented. A phase diagram for this two-component mixture has constructed, dependences its density refractive index temperature studied first time. molar refractivity under study calculated. possibility using as an extractant recovery metal ions in solid–liquid sys...

Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids (ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated. With all 14 odorants, the animals significantly discriminated concentrations as low as 0.03 ppm (parts per million) from the solvent, and with four odorants the best-scoring animals ...

Ab initio methods resolve mechanism behind carboxylic acid functionalisation of cobalt nanoparticles and identify the fate dissociated hydrogen atoms.

the present study describes the changes in expression of hydroxy- carboxylic acid receptor 2 (hca2 receptor) in femoral epiphysis and metaphysis of rats with glucocorticoid-induced osteoporosis (gio). 16 growing male sprauge dawley rats were randomly divided into two equal groups consisting of normal control and rats that were rendered osteoporotic by receiving 0.1 mg/kg/day dexamethasone throu...