Topical drug delivery systems have been used for centuries for the treatment of local skin disorders. One side the topical applications of the drug offer the potential advantages of delivering the drug directly to the site of action and delivering the drug for extended period of time at the effected site that mainly acts at the related regions. On the other hand, topical delivery system increas...

The influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. For this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of Carbopol 934P, 971P, 974P, Pemulen and Eudragit RLPO as retarding agents and inactive ingredients (e.g. PVP, Avicel or ...

Buccoadhesive drug delivery systems have distinct advantages in comparison with oral administration. Plant exudates like gum or mucilage are being studied for their use as pharmaceutical adjuvant. The aim of this study is to evaluate the properties of the Plantago major seed mucilage as a mucoadhesive agent and propranolol hydrochloride is chosen as a model drug. Mucoadhesive tablets of propran...

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic preparations due to rapid precorneal elimination, dilution and nasolacrimal drainage of the drug may be vanquished by the use of in situ gelling systems that are instilled as drops in to the eye and undergo a sol-gel transition in the cul-de-sac. Timolol eye drops may cause systemic side effects in glaucoma p...

buccoadhesive drug delivery systems have distinct advantages in comparison with oral administration. plant exudates like gum or mucilage are being studied for their use as pharmaceutical adjuvant. the aim of this study is to evaluate the properties of the plantago major seed mucilage as a mucoadhesive agent and propranolol hydrochloride is chosen as a model drug. mucoadhesive tablets of propran...

Purpose: The objective of this study was to prepare Propranolol Hydrochloride controlled release matrix tablets and to investigate the effect of the polymer blends and the polymer concentration on drug release. Method: Propranolol Hydrochloride controlled release matrix tablets were prepared by direct compression technique. Hydroxypropylmethylcellulose K15M (HPMC K15M) and Carbopol 934P were us...

In the present study, we prepared solid dispersions of water-insoluble and soluble drugs (ethenzamide (ETZ) and theophylline (THEO)) by the twin screw extruder method, which made it possible to control both kneading and heating at the same time under the fusion point of each drug, using three types of the controlled-release high-molecular-weight substance Carbopol (CAR) as the carrier. The soli...

Paula I Burgos & Graciela S Alarcón† †Author for correspondence The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology and Rheumatology, School of Medicine, Birmingham, AL, USA and, The University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 830 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35294–3408, USA...

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