The X-ray crystal structures of salts and zwitterionic Knoevenagel products from 1-dimethylamino-naphthalene-8-carbaldehyde show long N-C bonds between peri-groups which provide models for incomplete nucleophilic attack on a protonated carbonyl group and electron-deficient alkenes respectively. For the salts the N-C bonds lie in the range 1.625-1.638 Å with C-OH bonds intermediate in length bet...

Abstract Invited for the cover of this issue are Helfried Neumann, Matthias Beller and co‐workers at Leibniz‐Institut für Katalyse e. V., Rostock Hangzhou Normal University. The image depicts “the case ketone deuteration” being solved by Sherlock Holmes. Read full text article 10.1002/chem.202100468 .

Herein, a direct C8-oxygenation of naphthalene derivatives is described. Different carbonyl groups were used as directing group to deliver corresponding naphthols via palladium-catalyzed oxidation reaction using PhI(OAc)2 in TFA/TFAA mixture. Interestingly, when Weinreb amide was employed the group, naphtholactone skeleton directly obtained. This methodology applied synthesis variously substitu...

Studies have indicated that sports anemia is mainly associated with intravascular hemolysis induced by exercise. We hypothesized that such exercise-induced hemolysis leads to oxidative damage due to an increase in free iron caused by hematocyte destruction. Thirty-one male ICR mice were randomly divided into 3 groups: a rested control group, an intense-exercise group, and a group rested for 24 ...

Since the seminal work of Butlerov (1863) 1a and Grignard (1900), the addition of preformed organometallic reagents to carbonyl compounds has played a central role in chemical synthesis. While this technology has opened vast volumes of chemical space, the basicity of most organometallic reagents mandates “protection” of acidic substructures, including the ubiquitous hydroxyl group. For the synt...

The title compound, C(13)H(9)N(3)O(5), prepared as a solid derivative of 3-nitro-analine via reaction with 4-nitro-benzoyl chloride, crystallizes in a chiral space group. The mol-ecule is non-planar with a dihedral angle of 26.1 (1)° between the two benzene rings. Both nitro groups are twisted slightly out of the plane of their corresponding benzene rings, making dihedral angles of 10.7 (4) and...

Schiff bases are aldehyde or ketone like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The reaction is acid catalysed, however only aldehydes and ketones which do not aldolize easily in acidic media, can be condensed with amines in presence of strong acid ca...

In this work, the mild conditions of Mitsunobu reaction were used to convert the hydroxyl group of 6-triphenylmethylaminopenicillanyl alcohol to amines by using different nuleophiles such as phthalimide, ditert-butyliminodicarboxylate and potassium cyanate. The existence of the β-lactam carbonyl group increased the instability towards nucleophilic attack of refluxing methanol and the four-membe...