Background Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease characterized by the presence systemic inflammation, vasculitis, early-onset stroke, and hematologic manifestations such as cytopenia immunodeficiency. Mucocutaneous peripheral microvascular manifestations, livedo racemosa, cutaneous ulcers Raynaud’s phenomenon (RP), can occur, in up to 50%, 22% ...

Background Nail-fold capillaroscopy (NFC) is a non-invasive, in vivo diagnostic tool for the assessment of microvasculature proximal nail fold. The comprehensive approach based on four finger each hand excluding thumbs (in total eight fingers are examined) gold standard NFC evaluation and scoring. patient identified to have abnormal nailfold capillaries, if abnormality was present any finger/na...

Microcirculation disorders caused by thrombosis are the most important factor determining pathogenesis of organ damage in severe COVID-19 including absence obvious macrohemodynamic instability. However, there very few publications demonstrating results intravital visualization changes microcirculation system this disease. The objective: to assess state patients with viral pneumonia associated u...

A 40-year-old Japanese woman developed malignant-phase hypertension complicated by thrombotic microangiopathy, progressing to end-stage renal disease. Five years later, she was diagnosed with pulmonary arterial and interstitial pneumonia. Despite a lack of overt skin sclerosis, nucleolar staining in our indirect immunofluorescence analysis nailfold capillaroscopy facilitated the diagnosis anti-...

Peripheral microvascular impairment in systemic sclerosis (SSc) may be easily detected and scored in a safe noninvasive way by nailfold videocapillaroscopy (NVC). The paper highlights clinical conditions related to SSc in which NVC may represent an outcome measure of therapeutical interventions, by elaborating on their already assessed relationship with the NVC patterns and eventually scores. T...