Cannabis is now available to patients as a medicine in 18 states and the District of Columbia. Unfortunately, due to the long-standing prohibition, most providers have little information regarding the medicinal use of this versatile botanical. The history of cannabis as medicine will be reviewed. This presentation will summarize the main components of the plant and their pharmacologic effects, ...

Cannabis has been used in medicine for thousands of years prior to achieving its current illicit substance status. Cannabinoids, the active components of Cannabis sativa, mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervous system and CB2 found predominantly in cells involved w...

The majority of commercial Cannabis sativa L. (cannabis) cultivators use a 12.0-hour uninterrupted dark period to induce flowering; however, scientific information prove this is the optimal for all genotypes lacking. Knowing genotype-specific photoperiods may help promote growth by providing photoperiod photosynthesis. To determine whether floral initiation cannabis explants respond varied in v...

Recent studies have elucidated the biosynthetic pathway of cannabinoids and have highlighted the preference for a C-3 n-pentyl side chain in the most prominently represented cannabinoids from Cannabis sativa and their medicinally important decarboxylation products. The corresponding C-3 n-propyl side chain containing cannabinoids are also found, although in lesser quantities. Structure-activity...

The use of Cannabis sativa by humans dates back several thousand years, for both its psychotomimetic and potential medicinal properties. As scientific research methods developed, the cannabinoids present in this herb were characterized, as well as their complex interface with the human central nervous system, provided by the activation of specific receptors. The subsequent description of an end...

Objective: The present review provides a brief introduction into the endocannabinoid system and discusses main strategies of pharmacological interventions. Method: We have reviewed the literature relating to the endocannabinoid system and its pharmacology; both original and review articles written in English were considered. Discussion: Cannabinoids are a group of compounds present in Cannabis ...