Cannabinoids-endocannaboids are possible preventatives of common diseases including cancers. Cannabinoid receptors (CB(½), TRPV1) are central components of the system. Many disease-ameliorating effects of cannabinoids-endocannabinoids are receptor mediated, but many are not, indicating non-CBR signaling pathways. Cannabinoids-endocannabinoids are anti-inflammatory, anti-proliferative, anti-inva...

This review highlights the pharmacology, pharmacokinetics, pharmacological actions, therapeutic uses and adverse effects of cannabinoids. The effect of cannabinoids on anaesthesia is mentioned briefly. Important advances have taken place in cannabinoid research over the last few years and have led to the discovery of novel ligands. The possible clinical applications of these ligands and the dir...

Topical cannabinoids are increasingly utilized by dermatology patients for a range of disorders; however, the acceptance of these over-the-counter products has far outpaced scientific investigation into their safety and efficacy. Here, we review the studies of topical cannabinoids in skin conditions and assess their current place in dermatology practice.

Cannabinoids have been attracting a great deal of interest as potential anticancer agents. Originally derived from the plant Cannabis sativa, there are now a number of endo-, phyto- and synthetic cannabinoids available. This review summarizes the key literature to date around the actions, antitumor activity, and mechanisms of action for this broad range of compounds. Cannabinoids are largely de...

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Quantification of major cannabinoids in cannabis products is normally performed using high-pressure liquid chromatography (HPLC)-based methods. We propose a cost-effective alternative method that successfully separates and quantifies 14 single run capillary electrophoresis (CE) coupled with UV detector 18 min. The separation carried out 60% acetonitrile the presence 6.5 mM sodium hydroxide 25 µ...

The aim of our study was to evaluate the effects cannabinoids and serotonergic system on nociception in intact rats after heat stress. Cannabinoid receptor type 1 (CB1) 5-hydroxytryptamine (5НТ 1А ) agonists antagonists have been administered according different experimental designs (alone combinations) male Wistar rats, as well animals subjected one hour Pain perception has evaluated by Paw pr...

Cannabis sativa is a plant that has been used for millennia in the treatment of conditions such as chronic pain, rheumatism and epilepsy. Biochemical molecular studies have isolated its components, which are known cannabinoids, mapped complex system endogenous molecules receptors, endocannabinoid system. Studies report importance this physiopathology different organic disorders, fibromyalgia, P...

Preparations from Cannabis sativa (marijuana) have been used for many centuries both medicinally and recreationally. However, the chemical structure of their active components – the cannabinoids – was not elucidated until the early 1960s. Among the E60 cannabinoids produced by marijuana, D-tetrahydrocannabinol (THC) is the most relevant one owing to its high potency and abundance (Gaoni & Mecho...

Cannabinoids are a group of compounds synthesized exclusively by the Cannabis sativa plant, commonly known as marijuana. In 1990, the first cannabinoid-specific membrane (CB1) was characterized and cloned (Matsuda, Lolait, Brownstein, Young, & Bonner, 1990), which catapulted biomedical research on these unique compounds. Cannabinoids refer to both marijuanaderived compounds with the active ingr...