Breast cancer (BC) is the most frequent malignant neoplasia and leading cause of mortality for women. A timely diagnosis BC crucial to ensure best chances survival. Among various screening tools BC, antibodies directed towards self-antigens or tumor-associated antigens (autoantibodies) have emerged as an alternative image-based modalities. However, little attention has been paid global diversit...

in this study one lymph node from cow with viral lymphosarcoma and one lymph node from healthy cow were analyzed by three different methods for protein extraction, include simple homogenizing in pbs, sonication and phenol extraction. tumor antigen detection relies on immunoprecipitation followed by sds-page. in this experiment streptococcus pyogenes was used for purification of immune complexes...

interleukin (il)-17 is exclusively produced by cd4 helper t-cells upon activation. it most often acts as a pro-inflammatory cytokine, which stimulates the release of pro-inflammatory cytokines il-6, il-8, tnf-α, and granulocyte-macrophage colony-stimulating factor (gm-csf). in this study, we studied the in-vitro il-17 response to specific antigens and a variety of mitogens and compared the il-1...

background: to use different methods for serodiagnosis of ruminants' haemonchosis is important because detection of egg in the faeces is not so reliable. methods: peptide bands of 5 different crude antigens of intestine, uterus, cuticle, whole male and whole female of hae­monchus contortus were determined using sds-page and western blotting. five lambs were infected with 10,000 third stage larv...

HIGHLIGHTS IgG and IgA from normal human serum can recognize E. coli antigens LPS. The PBMC proliferation assay was induced by Mucosal may induce local systemic responses.

Nanoparticles (NPs) are effective and safe adjuvants for antigen delivery in modern vaccinology. Biodegradable nanomaterials with suitable properties are frequently applied for conjugation or loading with antigens; they protect the antigens from degradation in vivo. NPs are applied as effective delivery system to facilitate antigen uptake by antigen presenting cells (APCs) and especially dendri...

ulcerative colitis is an acute or chronic inflammatory bowel disease that diffusely involves the colonic mucosa. the etiology of ulcerative colitis is unknown. the involvement of genetic factors in ulcerative colitis is suggested by some reports of familial occurence anil the immune abnormalities found in patients and their unaffected female relatives. a number of disease with unknown etiology,...

background: thalassemia is probably the most common single gene disorder causing a major public health problem in the world. currently, allogenic hematopoietic stem cell transplantation (hsct) is the only curative therapy for thalassemia. one major limitation of hsct is the lack of hla-identical sibling donors, so attention has turned to finding phenotypically matched unrelated donors. patients...