Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

objective(s): the novel 7-hydroxycoumarinyl gallates derivatives are detected in many pharmaceutical compounds like anticancer and antimicrobial agents. whereas carbon nanotubes (cnts) have been discussed for nanomedicine applications and in particular as drug delivery systems. the capability of armchair (5, 5) swcnt -based drug delivery system in the therapy of anticancer has been investigated...

background: disulfiram is oral aldehyde dehydrogenase (aldh) inhibitor that has been used in the treatment of alcoholism. recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. encapsulation of disulfiram polymeric nanoparticles (nps) may improve its anticancer activities and protect rapid degradation of the drug. mater...

The expression of HNF1 homeobox B (HNF1B) is associated with cancer risk in several tumors, including ovarian cancer, and its decreased expression play roles in cancer development. However, the study of HNF1B and cancer is limited, and its association with drug resistance in cancer has never been reported. On the basis of array data retrieved from Oncomine and Gene Expression Omnibus (GEO) onli...

background: blood stream infection is one of the main causes of morbidity and mortality in patients with cancer. the purpose of this study was to evaluate the prevalence of aerobic and anaerobic-bacteremia in hospital inpatients with cancer and to determine the antibiotic resistance profile in isolated organisms in kerman, southeast iran.   methods: total of 240 blood cultures from 136 patients...

Recent advancements in cybergenetics have led to the development of new computational and experimental platforms that enable us robustly steer cellular dynamics by applying external feedback control. Such technologies never been applied regulate intracellular cancer cells. Here, we show silico adaptive model predictive control (MPC) can effectively be used simulated signalling Non-Small Cell Lu...

Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used to treat malaria autoimmune diseases for more than 70 years; they also immunomodulatory anticancer effects, which are linked autophagy autophagy-independent mechanisms. Herein, we review the pharmacokinetics, preclinical studies clinical trials investigating use of CQ HCQ as adjuvant agents in cancer therapy. We discuss their safety p...