نتایج جستجو برای: called nonstretch nmo

تعداد نتایج: 312950  

Journal: :Archives of neurology 2011
Akiyuki Uzawa Masahiro Mori Saeko Masuda Satoshi Kuwabara

OBJECTIVE To evaluate the degree of blood-brain barrier disruption in patients with neuromyelitis optica (NMO) and to clarify whether the levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) in patients with NMO can be useful biomarkers for blood-brain barrier breakdown. DESIGN Descriptive historical cohort. SETTING Department...

2016
Ting-Ting Yang Yang He Ya-Juan Xiang Dong-Hui Ao Yang-Yang Wang Qi Zhang Xiang-Jun He Shan-Shan Zhong Jian Wu Guang-Zhi Liu

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating disorders of the central nervous system (CNS). Various genetic and environmental factors have been identified to contribute to etiology of MS and NMO. Aquaporin 4 (AQP4), is the most abundant water channel in CNS. AQP4 is expressed in astrocytes of the brain, spinal cord, optic nerve and supportive cells in se...

Journal: :Frontiers in bioscience 2015
Kunihiko Asakura Akihiro Ueda Tatsuro Mutoh

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are presumed to be an autoimmune disease in the central nervous system (CNS). Although lipids are most abundant components in the nervous system, it has been believed that cellular and/or humoral immunity to various myelin proteins causes these neuroinflammatory diseases. Recent research advances enable us to study lipids in the membranes a...

2009
Masami Tanaka Keiko Tanaka Mika Komori

Background: The effects of interferon1b (IFN1b ) administration in multiple sclerosis (MS) patients have been confirmed, however, those in neuromyelitis optica (NMO) patients have not been shown. In this study, we assessed the effects of IFN1b treatment on disease exacerbation and disability progression in MS or NMO patients. Methods: We reviewed a series of 104 consecutive patients with relaps...

2009
M. Kim A. Chan H. Mak Q. Chan

Objective: Neuromyelitis optica (NMO) is an inflammatory and demyelinating disease of central nervous system that preferentially affects the optic nerve and spinal cord. NMO has long been thought of as a rare and severe variant of multiple sclerosis (MS), however, clinical, immunological and pathological characteristics that distinguish it from MS are now recognized [1]. As NMO involves recurre...

2006
Brian G. Weinshenker Dean M. Wingerchuk Sean J. Pittock Claudia F. Lucchinetti Vanda A. Lennon

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that principally targets the optic nerves and spinal cord and often leads to severe disability and occasionally life threatening respiratory failure. Although its clinical manifestations overlap with those of multiple sclerosis (MS), in established cases these two conditions can be distinguished on the basis of clinical, radiol...

Journal: :Disability and rehabilitation 2014
Kerry Mutch Abigail Methley Phil Moore Anu Jacob

PURPOSE Neuromyelitis optica (NMO) is a rare autoimmune condition characterised by acute relapses of optic neuritis and extensive transverse myelitis. The aim of this qualitative study was to develop an improved understanding of the experiences of people living with NMO. METHOD Fifteen participants completed a semi-structured interview and data were interpreted using a constant comparative me...

Journal: :Archives of neurology 2009
Nilufer Kale Sean J Pittock Vanda A Lennon Kristine Thomsen Shanu Roemer Andrew McKeon Claudia F Lucchinetti

T he pathogenic relationship between neuromyelitis optica (NMO) and multiple sclerosis (MS) continues to be debated despite mounting evidence that these are distinct entities. The NMO-IgG, which targets the water channel protein aquaporin-4 (AQP4), is the first confirmed serum biomarker for any form of central nervous system inflammatory demyelinating disease and reliably distinguishes NMO from...

Journal: :Archives of neurology 2006
Ilya Kister Sandeep Gulati Cavit Boz Roberto Bergamaschi Giovanni Piccolo Joel Oger Michael L Swerdlow

BACKGROUND Myasthenia gravis (MG) and neuromyelitis optica (NMO, also known as Devic disease) are rare autoimmune disorders, with upper-limit prevalence estimates in the general population of 15 per 100,000 and 5 per 100,000, respectively. To our knowledge, an association between these diseases has not been previously reported. OBJECTIVES To describe 4 patients with MG who developed NMO after...

2015
L Pandit N Asgari M Apiwattanakul J Palace F Paul MI Leite I Kleiter T Chitnis

The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0...

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