We used whole-cell patch-clamp techniques on presynaptic terminals and postsynaptic neurons of the glutamatergic magnocellularis synapse in the chick auditory brainstem to study the effects of N, P, and L-type calcium channel blockers directly on presynaptic calcium currents and transmitter release. Presynaptic calcium currents and transmitter release were unaffected by nifedipine, blocked part...

Urolithiasis is a polyetiological and polypathogenetic disease. The modern task of treatment SCC not only the elimination calculus, but also prevention causes that led to its formation. lack comprehensive approach correction metabolic disorders leads fact 7-10% patients after removal calculus relapse within 1 year, 35% - 5 years 50% 10 years. mean time recurrence in every second patient 8.8 ± 1...

All subtypes of KCNQ channel subunits (KCNQ1-5) require calmodulin as a co-factor for functional channels. It has been demonstrated that calmodulin plays a critical role in KCNQ channel trafficking as well as calcium-mediated current modulation. However, how calcium-bound calmodulin suppresses the M-current is not well understood. In this study, we investigated the molecular mechanism of KCNQ2 ...