نتایج جستجو برای: cakut
تعداد نتایج: 175 فیلتر نتایج به سال:
OBJECTIVE The abnormalities of the genitourinary tract development are the leading cause of chronic kidney disease (CKD) in children. The diagnosis of this disease in Brazil is late and incomplete, which results in increased morbidity and mortality in this age group. Early diagnosis of this condition is the prerogative of generalist pediatricians, and the aim of this study was to review the cli...
The development of the mammalian kidney is a highly complex process dependent upon the interplay of various cell types, secreted morphogens, and the extra-cellular matrix (ECM). Although integrins are the most important receptors for ECM proteins and are ubiquitously expressed during kidney development, mice lacking expression of integrin α3 (Itga3) do not demonstrate a reduced number of nephro...
The Wnts can be considered as candidates for the Congenital Anomaly of Kidney and Urinary Tract, CAKUT diseases since they take part in the control of kidney organogenesis. Of them Wnt5a is expressed in ureteric bud (UB) and its deficiency leads to duplex collecting system (13/90) uni- or bilateral kidney agenesis (10/90), hypoplasia with altered pattern of ureteric tree organization (42/90) an...
Abstract Background The European Rare Kidney Disease Reference Network (ERKNet) recently established ERKReg, a Web-based registry for all patients with rare kidney diseases. main objectives of this core are to generate epidemiological information, identify current patient cohort clinical research, explore diagnostic and therapeutic management practices, monitor treatment performance patient’s o...
Abstract Background and Aims Despite advances in understanding the underlying causes of CKD, 20% cases remain unexplained (1). A genomic approach has potential to identify cause CKD a significant portion pediatric adult patients, with estimated diagnostic rates 5-30% (2). However, there is lack consensus scientific community on best algorithm. The DECIDE project (Diagnostic EffiCacy kIdney Dise...
The development of the mammalian kidney, or metanephros, occurs in a region of posterior intermediate mesoderm by inductive interactions between the metanephric mesenchyme and the ureteric bud epithelium (Kuure et al., 2000; Lechner and Dressler, 1997; Schedl and Hastie, 2000). Induction of the mesenchyme by signals emanating from the bud initiates the aggregation of the mesenchyme and the conv...
Background Renal diseases are major causes of morbidity and mortality in pediatric practice. Pediatric patients with renal disease, especially younger ones may present with nonspecific signs and symptoms unrelated to the urinary tract. Unexplained fever or failure to thrive may be the only manifestation. Most children with renal diseases in our hospital arrive very late either because of inadeq...
#5114 THE GENOTYPE DISTRIBUTION IN A SINGLE-CENTRE COHORT OF PATIENTS WITH POLYCYSTIC KIDNEY DISEASE
Abstract Background and Aims Polycystic kidney disease (PKD) is one of the most common causes chronic (CKD) could lead to end-stage (ESKD) both in adulthood childhood. In last few years many genes were discovered be associated with PKD beyond classical PKD1 PKD2, that account for majority patients ADPKD (Autosomal Dominant Kidney Disease), PKHD1 DZIPIL are responsible ARPKD Recessive Disease). ...
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