PURPOSE Identification of cancer/testis antigens useful for diagnosis or immunotherapy of cancers was attempted by cDNA expression cloning with patients' sera (SEREX). EXPERIMENTAL DESIGN cDNA expression libraries made from testis or endometrial cancer cell lines were screened using sera from patients with endometrial cancer or melanoma patients immunized with dendritic cells pulsed with auto...

A Faraday cage structure using through-substrate vias is an effective strategy to suppress substrate crosstalk, particularly at high frequencies. Faraday cages can reduce substrate noise by 32 dB at 10 GHz, and 26 dB at 50 GHz. We have developed lumped-element, equivalent circuit models of the Faraday cages and test structures to better understand the performance of the Faraday cages. These mod...

GroEL and GroES form a chaperonin nano-cage for proteins up to approximately 60 kDa to fold in isolation. Here we explored the structural features of the chaperonin cage critical for rapid folding of encapsulated substrates. Modulating the volume of the GroEL central cavity affected folding speed in accordance with confinement theory. Small proteins (approximately 30 kDa) folded more rapidly as...

OBJECTIVE This study was undertaken to quantify the in vitro range of motion (ROM) of oblique as compared with anterior lumbar interbody devices, pullout resistance, and subsidence in fatigue. METHODS Anterior and oblique cages with integrated plate fixation (IPF) were tested using lumbar motion segments. Flexibility tests were conducted on the intact segments, cage, cage + IPF, and cage + IP...

Indicators of environmental adequacy relevant to the well-being of small felids are developed by examining, in 4 captive leopard cats, interrelationships between behavioral and adrenocortical responses to changes in housing conditions. Singly housed cats were moved from their barren home cage (Cage 1, baseline) sequentially to 2 new, barren housing situations (Cages 2 and 3; =10 weeks/cage). Ur...

In paper I of this series, a molecular dynamics ~MD! study of liquid chlorine was performed, and it includes the definition and observation of operational cage variables. These cage variables were used to describe the local environment of a rotating axially symmetric molecule, or probe. Probe and cage properties of interest, such as rotational correlation functions and momentum correlation func...

This study was carried out to investigate the effects of different breeding systems (breeding on the ground and in the cage) on the egg production and egg characteristics of Rock Partridges. Egg production values of the ground and cage system groups were determined as 41.30 and 49.40%, respectively, and this difference was found to be significant (P < 0.05). The weight values of the eggs were 2...

The GroEL/GroES chaperonin system of Escherichia coli forms a nano-cage allowing single protein molecules to fold in isolation. However, as the chaperonin can also mediate folding independently of substrate encapsulation, it remained unclear whether the folding cage is essential in vivo. To address this question, we replaced wild-type GroEL with mutants of GroEL having either a reduced cage vol...

Molecular organic cage compounds have attracted considerable attention due to their potential applications in gas storage, catalysis, chemical sensing, molecular separations, etc. In this study, a homochiral pentyl cage compound was synthesized from a condensation reaction of (S,S)-1,2-pentyl-1,2-diaminoethane and 1,3,5-triformylbenzene. The imine-linked pentyl cage diluted with a polysiloxane ...

Background: Interbody cage stabilization as a stand-alone procedure in lumbar spine fusion is questioned due to inconsistent mechanical effects registered in human cadaveric studies. Even segmental mobility exceeding the normal range of motion is described after cage implantation. For the anterior interbody cage fusion, this potential, undesired destabilization is explained by the resection of ...