The effect of vitamin B-complex on cadmium nephrotoxicity and hepatotoxicity was investigated in rats. The administration of Cd (3 mg per kg, s.c., three days) increased the urinary excretions of lactic dehydrogenase (LDH), glutamic oxalacetic transaminase (GOT), and total proteins, decreased renal activities LDH and GOT and increased concentration in kidney tissue of Cd, Cu, and Zn, Cadmium al...

Cadmium is a known renal toxin. The cytotoxic effect of cadmium chloride (CdCl2) was evaluated on renal inner medullary collecting duct cells (mIMCD3). The 24 hr LC50 value for CdCl2 in mIMCD3 cells was 40 µM. The present study showed that mIMCD3 cells were sensitive to CdCl2 exposure.

The present study investigated the protective effect of thymoquinone (TQ), against cadmium-induced kidney injury in rats. Cadmium chloride (1.2 mg Cd/kg/day, s.c.), was given for nine weeks. TQ treatment (40 mg/kg/day, p.o.) started on the same day of cadmium administration and continued for nine weeks. TQ significantly decreased serum creatinine, renal malondialdehyde and nitric oxide, and sig...

Datura innoxia cells from suspension cultures were selected for their ability to grow and divide rapidly in normally lethal concentrations of cadmium. Cells resistant to 12.5, 25, 50, 100, 160, 200, and 250 micromolar cadmium chloride were isolated and utilized to initiate cell suspension cultures resistant to this toxic metal ion. Variant cell lines retained their ability to grow in cadmium af...

Male Wistar rats were exposed to a water solution of cadmium chloride (labelled with cadmium-109) at a dose corresponding to 10 mg Cd/kg diet for 28 days. Carcass, hepatic, renal and testicle distribution of cadmium was studied for 32 days after dosing. Our results indicate that the carcass deposition of cadmium was at a comparative level during the experimental period. Hepatic distribution pat...

The use of electrodialysis to remove cadmium from water has been shown to be feasible for a wide range of conditions. As much as three orders of magnitude reduction in the concentration of cadmium was observed for the feed with the concentrate stream from the process containing cadmium concentrations greater than 100,OOO ppm. The effect of cadmium concentration, pH, and added sodium chloride co...

The teratogenicity of cadmium chloride (16 pM/kg Cd++) was studied in Wistar rats from two commercial sources. Subcutaneous cadmium was not teratogenic. Intraperitoneal cadmium was highly teratogenic in both stocks when given on day 9, 10, or 11 of gestation. There were marked differences between the two stocks in fetal mortality and the incidence and types of malformations produced. Cadmium on...

Though our previous study has showed that pretreatment with Orthosiphon Stamineus methanol extract (OSM) prevents gentamycin induced nephrotoxicity. No report has been documented on the effect of Pretreatment of OSM with Cadmium and Lead. Therefore this study aims to investigating the effect of pretreatment with OSM on Cadmium and Lead induced Nephrotoxicity. Nephrotoxicity was induced in Wista...

This study investigated the role of Na(+)/H(+) exchanger (NHE) and signalling molecules, such as cAMP, PKC, PI 3-kinase, and immune defence enzymes, NADPH oxidase and nitric oxide synthase, in the induction of protein glutathionylation and carbonylation in cadmium-treated haemocytes of mussel Mytilus galloprovincialis. Glutathionylation was detected by western blot analysis and showed actin as ...

Diverse organismsuch as mammals and fishes exposure to noxious waste in the surroundings is a continuous routine active absorption propagation of contaminants humans through food chain. In order determine level toxicity across chain,this research was structured identify some biochemical alterations hepatic tissue rats fed cadmium, cyanide mixture cadmium contaminated catfish diet. Fish were ass...