نتایج جستجو برای: caco 2 cell

تعداد نتایج: 3839619  

Journal: :Biological & pharmaceutical bulletin 2013
Mingming Chang Xiaohui Li Yuming Sun Fang Cheng Yueqing Li Weijie Zhao Qing Wang

Effective delivery of therapeutic biomolecules across biomembranes is a challenging topic. A cationic cyclopeptide named TD-34 (ACSSKKSKHCG) was reported to improve insulin delivery across biomembranes effectively. Based on our previous work, we investigated the mechanism of TD-34 for enhancing insulin across Caco-2 cell monolayers. Transport studies of insulin, TD-34 and insulin accompanied wi...

2001
H M Roche M J Gibney D Kelleher

Conjugated linoleic acid (CLA) is a collective term referring to the positional and geometric isomers of linoleic acid. This novel fatty acid has been shown to have a number of beneficial actions, including immunomodulatory, anticarcinogenic, and antiatherogenic eVects. Tight junctions of epithelial cells determine epithelial membrane integrity and selective paracellular permeability to ions an...

Journal: :Journal of cell science 2004
Hao Pang Phuong U Le Ivan R Nabi

Cholera toxin is associated with caveolae and raft domains in various cell types and previous studies have shown that cholera toxin can be internalized by caveolae/raft-dependent endocytosis as well as by other pathways. We undertook the study of cholera toxin endocytosis in CaCo-2 and HeLa cells. CaCo-2 cells do not express detectable levels of caveolin and, relative to HeLa cells, also presen...

Journal: :Applied and environmental microbiology 2009
Glen E Mellor Rebecca M Goulter T W Raymond Chia Gary A Dykes

The ability of Escherichia coli and Salmonella isolates to attach to Caco-2 and HT-29 cell monolayers was measured. All isolates displayed a greater ability to attach to Caco-2 cells than HT-29 cells, and overall E. coli isolates attached better to both cell lines than Salmonella isolates. Bacteria that were considered to be pathogenic displayed no greater ability to attach to cell lines than t...

A. Hadjiakhoondi M. Khanavi N. Khosravi Dehaghi N. Maafi S. N. Ostad S. Pedram Y. Ajani

Salvia is one of the largest genera of  Lamiaceae family. Several species of this genus are perfumed and wealthy in essential oils. Some of them are used in industry, pharmacy and aromatherapy. They have shown different biological effects such as antibacterial and antioxidant activity. For the present study, Salvia verticillata L. was collected from Shahrestanak, Mazandaran, I...

In this study, N,N-Dimethyl-N-Octyl chitosan was synthesized. Nanoparticles containing insulin were prepared using PEC method and were statistically optimized using the Box-Behnken response surface methodology. The independent factors were considered to be the insulin concentration, concentration and pH of the polymer solution, while the dependent factors were characterized as the size, zeta po...

Journal: :Planta medica 2016
Hong Li Jie Li Lu Liu Yichuan Zhang Yili Luo Xiaoli Zhang Peng Yang Manna Zhang Weifeng Yu Shen Qu

Celastrol, a triterpenoid isolated from stem (caulis) of Celastrus orbiculatus Thunb. (Celastraceae), has been known to have various pharmacological effects, including anti-inflammatory, anticancer, and antioxidant activities. However, the mechanism of the intestinal absorption of celastrol is unknown. The aim of this study was to investigate the intestinal absorption of celastrol using the Cac...

2014
Georgios D. Ayiomamitis George Notas Apostolos Zaravinos Ioannis Drygiannakis Maria Georgiadou Ourania Sfakianaki Niki Mastrodimou Kyriaki Thermos Elias Kouroumalis

Peptide hormone somatostatin and its receptors have a wide range of physiological functions and play a role in the treatment of numerous human diseases, including colorectal cancer. Octreotide, a synthetic somatostatin-analog peptide, inhibits growth of colonic cancer cells primarily by binding to G-protein coupled receptors and elicits cellular responses through second-messenger systems. Insul...

Journal: :Journal of Biomedicine and Biotechnology 2008
Alicja Jankowska Daniel Laubitz Hanna Antushevich Romuald Zabielski Elżbieta Grzesiuk

Competition of commensal and probiotic bacteria with pathogens for adhesion and colonization is one of the important protective mechanisms of gastrointestinal tract. In this study, we examined the ability of Lactobacillus paracasei to inhibit the adhesion of pathogenic Salmonella enterica to human colon adenocarcinoma Caco-2 cells. Caco-2 cells were grown for 6 or 21 days to obtain nondifferent...

2013
Monique Albersen Marjolein Bosma Nine V. V. A. M. Knoers Berna H. B. de Ruiter Eugène F. Diekman Jessica de Ruijter Wouter F. Visser Tom J. de Koning Nanda M. Verhoeven-Duif

BACKGROUND Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6. In literature, the liver has been reported to be the major site for this conversion, whereas the exact role of the intestine remains to be elucidated. OBJECTIVE To gain insight into the role of the intestine in human vitamin...

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