BACKGROUND Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number of in vitro and in vivo studies have reported that hypoxia can induce amyloid-β peptide accumulation through various molecular mechanisms including the up-regulation of the amyloid-β precursor protein, the β-secretase Bace1, or the γγ-secretase complex components, as well as th...

This paper aims to establish a delayed dynamical relationship between payoffs of players in a zero-sum game. By introducing Markovian chain and time delay in the network model, a delayed game network model with sector bounds and slope bounds restriction nonlinear function is first proposed. As a result, a direct dynamical relationship between payoffs of players in a zero-sum game can be illustr...

Using constraint-based local search, we effectively model and efficiently solve the problem of balancing the traffic demands on portions of the European airspace while ensuring that their capacity constraints are satisfied. The traffic demand of a portion of airspace is the hourly number of flights planned to enter it, and its capacity is the upper bound on this number under which air-traffic c...

Demand for business intelligence solutions continues to grow in the industry at record rates to combat competitive pressures and to attain business agility. Still organizations continue to struggle on how to implement successful business intelligence solutions. Despite its growing popularity and maturity as a field, it appears that organizations follow key guidelines that ensure the failure of ...

A within-day dynamic demand model is formulated, embodying, in addition to the classic generation, distribution and modal split stages, an actual demand model taking into account departure time choice. The work focuses on this last stage, represented through an extension of the discrete choice framework to a continuous choice set. The dynamic multimodal supply and equilibrium model based on imp...

Currently a new version of the distance education platform WeLearn [3] to be combined with an agent system ([1], also developed locally) for providing advanced services [2] is under development. In a previous stage of the project software was created to automatically derive keywords from documents, either from the different versions of metadata already contained (various Microsoft file formats,...