An enantioselective synthesis of (−)-10-hydroxyacutuminine is reported. Central to our strategy a photochemical [2+2] cycloaddition that forges two the quaternary stereocenters present in acutumine alkaloids. A subsequent retro-aldol/Dieckmann sequence furnishes spirocyclic cyclopentenone. Efforts chlorinate scaffold at C10 under heterolytic or radical deoxychlorination conditions led an unexpe...

Chemometric method such as cluster and principal component analyses applied for alkanes C6-C10 detection in the air. To increase piezosensor selectivity to analytes L-apiezon is applied as active modifier. It is shown that processing of piezosensor signals to analytes with cluster and principal component analyses allows to refer (to identify) substance to the appropriate alkane (hexane, heptane...

C. Zaouter1, J. Calderon1 and T. M. Hemmerling2,3,4* 1 CHU de Bordeaux, Service d’Anesthésie-Réanimation II, F-33000 Bordeaux, France 2 Department of Anesthesia, McGill University, MUHC, Institute of Biomedical Engineering, Université de Montréal, Montreal, Canada 3 ITAG Laboratory, Canada 4 Arnold and Blema Steinberg Medical Simulation Centre, Montreal General Hospital, Room: C10–153, 1650 Ced...

A concise synthesis of a highly functionalized intermediate lacking only C10 of the mitomycin backbone is described. The key to this development is the Brønsted acid-catalyzed aza-Darzens reaction used to forge the cis-aziridine. Additionally an oxidative ketalization fortuitously occurs during the quinone-enamine coupling step, leading to an orthogonally protected hydroquinone.

This paper was written to mark the 50th anniversary of Neyman and Scott's Econometrica paper de"ning the incidental parameter problem. It surveys the history both of the paper and of the problem in the statistics and econometrics literature. ( 2000 Elsevier Science S.A. All rights reserved. JEL classixcation: B23; C10

Figure S1. Time‐dependent UV‐vis absorbance spectra of the MO solution in the presence (a) TiO2; (b) BiOI/TiO2‐C10; (c) BiOI/TiO2‐C20; (d) BiOI/TiO2‐C30; (e) mechanical mixture of BiOI and TiO2 (M‐BT) under UV light irradiation; (f) EDX of BiOI/TiO2‐C30 (Bi:Ti = 0.4:1).

PURPOSE Cocoa intake has been associated with health benefits, improving cardiovascular function and metabolism, as well as modulating intestinal immune function. The aim of this study was to take an in-depth look into the mechanisms affected by the cocoa intake by evaluating the colonic gene expression after nutritional intervention, and to ascertain the role of the fiber of cocoa in these eff...