نتایج جستجو برای: c albicans

تعداد نتایج: 1068200  

Journal: :Infection and immunity 2009
Caroline V Bamford Anita d'Mello Angela H Nobbs Lindsay C Dutton M Margaret Vickerman Howard F Jenkinson

The fungus Candida albicans colonizes human oral cavity surfaces in conjunction with a complex microflora. C. albicans SC5314 formed biofilms on saliva-coated surfaces that in early stages of development consisted of approximately 30% hyphal forms. In mixed biofilms with the oral bacterium Streptococcus gordonii DL1, hyphal development by C. albicans was enhanced so that biofilms consisted of a...

Journal: :Sexually transmitted infections 2008
S R Fan F Y Bai Q P Liao Z H Liu J Li X P Liu

OBJECTIVE To compare genotypes of Candida albicans strains causing different conditions of vulvovaginal candidiasis (VVC) in Chinese women. METHODS C albicans strains were isolated from the vaginas of patients with different conditions of VVC. The genotypes of the strains were investigated based on single-strand conformation polymorphisms (SSCP) of the PCR amplified microsatellite locus CAI. ...

2016
Fengliang Liu Xiuzhen Fan Sarah Auclair Monique Ferguson Jiaren Sun Lynn Soong Wei Hou Robert R. Redfield Deborah L. Birx Silvia Ratto-Kim Merlin L. Robb Jerome H. Kim Nelson L. Michael Haitao Hu

Loss of immune control over opportunistic infections can occur at different stages of HIV-1 (HIV) disease, among which mucosal candidiasis caused by the fungal pathogen Candida albicans (C. albicans) is one of the early and common manifestations in HIV-infected human subjects. The underlying immunological basis is not well defined. We have previously shown that compared to cytomegalovirus (CMV)...

Journal: :Antimicrobial agents and chemotherapy 2014
Nicolas Delattin Katrijn De Brucker David J Craik Olivier Cheneval Mirjam Fröhlich Matija Veber Lenart Girandon Talya R Davis Anne E Weeks Carol A Kumamoto Paul Cos Tom Coenye Barbara De Coninck Bruno P A Cammue Karin Thevissen

We previously identified a decapeptide from the model plant Arabidopsis thaliana, OSIP108, which is induced upon fungal pathogen infection. In this study, we demonstrated that OSIP108 interferes with biofilm formation of the fungal pathogen Candida albicans without affecting the viability or growth of C. albicans cells. OSIP108 displayed no cytotoxicity against various human cell lines. Further...

2017
Fabien Cottier Alrina Shin Min Tan Marina Yurieva Webber Liao Josephine Lum Michael Poidinger Francesca Zolezzi Norman Pavelka

Candida albicans is a resident fungus of the human intestinal microflora. Commonly isolated at low abundance in healthy people, C. albicans outcompetes local microbiota during candidiasis episodes. Under normal conditions, members of the human gastrointestinal (GI) microbiota were shown to keep C. albicans colonization under control. By releasing weak organic acids (WOAs), bacteria are able to ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Matthew D Disney Constantine G Haidaris Douglas H Turner

Candida albicans is a significant cause of disease in immunocompromised humans. Because the number of people infected by fungal pathogens is increasing, strategies are being developed to target RNAs in fungi. This work shows that oligonucleotides can serve as therapeutics against C. albicans. In particular, oligonucleotides are taken up from cell culture medium in an energy-dependent process. A...

2013
Alistair J. P. Brown Susan Budge Despoina Kaloriti Anna Tillmann Mette D. Jacobsen Zhikang Yin Iuliana V. Ene Iryna Bohovych Doblin Sandai Stavroula Kastora Joanna Potrykus R. Ballou Delma S. Childers Shahida Shahana

Candida albicans is a major fungal pathogen of humans. This yeast is carried by many individuals as a harmless commensal, but when immune defences are perturbed it causes mucosal infections (thrush). Additionally, when the immune system becomes severely compromised, C. albicans often causes life-threatening systemic infections. A battery of virulence factors and fitness attributes promote the p...

Journal: :Japanese journal of infectious diseases 2005
Hossein Mirhendi Koichi Makimura Kamiar Zomorodian Nobuko Maeda Tomoko Ohshima Hideyo Yamaguchi

Candida dubliniensis is a novel Candida spp. that is similar to Candida albicans with respect to several phenotypic characteristics. However, they differ from each other with respect to epidemiology, pathogenesis, and the rapid development of resistance to fluconazole. In the present study, we used a single-enzyme PCR-restriction fragment length polymorphism (RFLP) technique to differentiate C....

2014
Hong-Leong Cheah Vuanghao Lim Doblin Sandai

Candida albicans is an opportunistic pathogen that causes candidiasis in humans. In recent years, metabolic pathways in C. albicans have been explored as potential antifungal targets to treat candidiasis. The glyoxylate cycle, which enables C. albicans to survive in nutrient-limited host niches and its. Key enzymes (e.g., isocitrate lyase (ICL1), are particularly attractive antifungal targets f...

Journal: :Molecular biology of the cell 2003
Brice Enjalbert André Nantel Malcolm Whiteway

We used transcriptional profiling to investigate the response of the fungal pathogen Candida albicans to temperature and osmotic and oxidative stresses under conditions that permitted >60% survival of the challenged cells. Each stress generated the transient induction of a specific set of genes including classic markers observed in the stress responses of other organisms. We noted that the clas...

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